410095-16-8Relevant articles and documents
An improved synthesis of the C15-C28 fragment of laulimalide
Sivaramakrishnan,Nadolski, Geoffry T.,McAlexander, Ian A.,Davidson, Bradley S.
, p. 213 - 216 (2007/10/03)
The C15-C28 fragment of the paclitaxel-like antimicrotubule agent laulimalide has been synthesized in 12 linear steps from known epoxide 5, with an overall yield of 16%. The methyldihydropyran ring of the side chain was efficiently prepared using ring-closing olefin metathesis chemistry. The 19,20-diol stereochemistry originates in starting material 7 and the side chain was appended using a Kocienski-modified Julia coupling.