4103-60-0

Basic information

• Product Name: 2-AMINOPHENYLACETAMIDE
• Synonyms: 2-AMINOPHENYLACETAMIDE;O-AMINOPHENYLACETAMIDE;Acetamide, 2-(o-aminophenyl)- (7CI,8CI);2-(2-azanylphenyl)ethanamide
• CAS NO: 4103-60-0
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Product Categories: AMINEPRIMARY
• Mol File: 4103-60-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 399.6 °C at 760 mmHg
• Flash Point: 195.5 °C
• Appearance: /
• Density: 1.198 g/cm³
• Vapor Pressure: 1.35E-06mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: 2-AMINOPHENYLACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINOPHENYLACETAMIDE(4103-60-0)
• EPA Substance Registry System: 2-AMINOPHENYLACETAMIDE(4103-60-0)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 4103-60-0(Hazardous Substances Data)

Usage

General Description

2-Aminophenylacetamide, also known as 2-APA, is a chemical compound with the molecular formula C8H9NO. This white crystalline solid is an amide derivative of acetanilide and has a wide range of applications in the pharmaceutical and chemical industries. It is commonly used as a building block in the synthesis of various pharmaceutical drugs and as an intermediate in the production of dyes and pigments. 2-APA has also been investigated for its potential analgesic and anti-inflammatory properties, and research continues to explore its therapeutic potential in various medical conditions. However, it is important to handle 2-APA with caution as it may pose risks to human health and the environment if not properly managed and disposed of.

InChI:InChI=1/C8H10N2O/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4H,5,9H2,(H2,10,11)

Upstream product

• 861560-54-5 nitro-phenyl-acetic acid amide 
• 6591-61-3 (S)-Phenylglycine methyl ester 
• 31142-60-6 2-(2-nitrophenyl)acetamide 

Downstream Products

• 58884-30-3 (2-acetylamino-phenyl)-acetic acid amide 
• 62779-70-8 (1S)-1-phenylethylene-1,2-diamine 

Relevant articles and documents

Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site

The NAD+-dependent deacetylase SIRT2 represents an attractive target for drug development. Here, we designed and synthesized drug-like SIRT2-selective inhibitors based on an analysis of the putative binding modes of recently reported SIRT2-selective inhibitors and evaluated their SIRT2-inhibitory activity. This led us to develop a more drug-like diketopiperazine structure as a "hydrogen bond (H-bond) hunter" to target the substrate-binding site of SIRT2. Thioamide 53, a conjugate of diketopiperazine and 2-anilinobenzamide which is expected to occupy the "selectivity pocket" of SIRT2, exhibited potent SIRT2-selective inhibition. Inhibition of SIRT2 by 53 was mediated by the formation of a 53-ADP-ribose conjugate, suggesting that 53 is a mechanism-based inhibitor targeting the "selectivity pocket", substrate-binding site, and NAD+-binding site. Furthermore, 53 showed potent antiproliferative activity toward breast cancer cells and promoted neurite outgrowth of Neuro-2a cells. These findings should pave the way for the discovery of novel therapeutic agents for cancer and neurological disorders.