41038-35-1

Basic information

• Product Name: Benzene, 1-(2-bromo-1,2-diphenylethenyl)-4-methoxy-, (E)-
• CAS NO: 41038-35-1
• Molecular Formula: C21H17BrO
• Molecular Weight: 365.269
• Mol File: 41038-35-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(2-bromo-1,2-diphenylethenyl)-4-methoxy-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(2-bromo-1,2-diphenylethenyl)-4-methoxy-, (E)-(41038-35-1)
• EPA Substance Registry System: Benzene, 1-(2-bromo-1,2-diphenylethenyl)-4-methoxy-, (E)-(41038-35-1)

Safety Data

• Hazardous Substances Data: 41038-35-1(Hazardous Substances Data)

Upstream product

• 696-62-8 para-iodoanisole 
• 501-65-5 diphenyl acetylene 
• 1233-23-4 (E)-1-(4-methoxyphenyl)-1,2-diphenylethylene 
• 72474-39-6 4-(1,2-diphenylvinyl)anisole 

Downstream Products

• 1233-23-4 (E)-1-(4-methoxyphenyl)-1,2-diphenylethylene 
• 1233-23-4 (Z)-1-(4-methoxyphenyl)-1,2-diphenylethylene 
• 17932-18-2 3-(4-methoxyphenyl)-2-phenyl-1H-inden-1-one 
• 70603-19-9 6-methoxy-2,3-diphenyl-1H-inden-1-one 
• 5543-97-5 2-(4-methoxyphenyl)-1,2-diphenylethan-1-one 
• 846541-57-9 3t-(4-methoxy-phenyl)-2,3c-diphenyl-acrylic acid 
• 879008-28-3 3c-(4-methoxy-phenyl)-2,3t-diphenyl-acrylic acid 

Relevant articles and documents

Trans-stilbene as a starting material for the synthesis of tamoxifen based on palladium-catalyzed cross-coupling reactions

(Z)-Tamoxifen was synthesized from a simple olefin (trans-stilbene) in 5 steps and 40% overall yield (Z/E = 74:26). The phenyl substituted group (4-Me2NCH2CH2OC6H4) was attached by a bromination-dehydrobromination-Suzuki reaction sequence. Subsequently, the ethyl group was attached to the triarylated olefin by a bromination-Negishi reaction sequence. Both the Suzuki and Negishi cross-coupling processes are stereospecific, and the stereo-selectivity depends only on the bromination-dehydrobromination reactions. (Z)-Tamoxifen was also obtained from trans-stilbene in only 3 steps by using Heck reaction-bromination- Negishi reaction sequence in 57% overall yield (Z/E = 65:35). Georg Thieme Verlag Stuttgart.