41042-20-0

Basic information

• Product Name: (2,3-DIOXO-2,3-DIHYDRO-INDOL-1-YL)-ACETIC ACID METHYL ESTER
• Synonyms: METHYL (2,3-DIOXO-2,3-DIHYDRO-1H-INDOL-1-YL)ACETATE;(2,3-DIOXO-2,3-DIHYDRO-INDOL-1-YL)-ACETIC ACID METHYL ESTER;TIMTEC-BB SBB006855
• CAS NO: 41042-20-0
• Molecular Formula: C₁₁H₉NO₄
• Molecular Weight: 219.19
• Mol File: 41042-20-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2,3-DIOXO-2,3-DIHYDRO-INDOL-1-YL)-ACETIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2,3-DIOXO-2,3-DIHYDRO-INDOL-1-YL)-ACETIC ACID METHYL ESTER(41042-20-0)
• EPA Substance Registry System: (2,3-DIOXO-2,3-DIHYDRO-INDOL-1-YL)-ACETIC ACID METHYL ESTER(41042-20-0)

Safety Data

• Hazardous Substances Data: 41042-20-0(Hazardous Substances Data)

Usage

Description

(2,3-DIOXO-2,3-DIHYDRO-INDOL-1-YL)-ACETIC ACID METHYL ESTER is a methyl ester derivative of the indole-2,3-dione, a chemical compound with potential therapeutic applications in the pharmaceutical industry.
Used in Pharmaceutical Industry:
(2,3-DIOXO-2,3-DIHYDRO-INDOL-1-YL)-ACETIC ACID METHYL ESTER is used as a key intermediate in the synthesis of drugs targeting the central nervous system for its potential therapeutic applications.
Used in Neurological Disorders Treatment:
(2,3-DIOXO-2,3-DIHYDRO-INDOL-1-YL)-ACETIC ACID METHYL ESTER is used as a potential therapeutic agent for treating neurological disorders such as Alzheimer's disease and Parkinson's disease, due to its ability to modulate neurotransmitter systems.
Used in Anti-Inflammatory and Analgesic Applications:
(2,3-DIOXO-2,3-DIHYDRO-INDOL-1-YL)-ACETIC ACID METHYL ESTER may also have potential as an anti-inflammatory and analgesic agent, although further research is needed to fully understand its pharmacological properties and potential uses.

Upstream product

• 91-56-5 indole-2,3-dione 
• 96-34-4 methyl chloroacetate 
• 5199-50-8 methyl 2-iodoacetate 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 60705-96-6 (2,3-Dioxo-2,3-dihydro-1H-indol-1-yl)acetic acid 

Relevant articles and documents

Palladium catalyzed divergent cycloadditions of vinylidenecyclopropane-diesters with methyleneindolinones enabled by zwitterionic π-propargyl palladium species

A palladium-catalyzed divergent synthesis of spirooxindoles fused with a five- or a six-membered ring by a cycloaddition reaction of vinylidenecyclopropane-diesters with methyleneindolinones was disclosed. This protocol features anin situgenerated unprecedented zwitterionic π-propargyl palladium species in cycloaddition reactions and a switchable process between (3+2) and (4+2) cycloadditions by changing the phosphine ligand.

Polyfunctional 4-quinolinones. Synthesis of 2-substituted 3-hydroxy-4-oxo-1,4-dihydroquinolines

We present here two new methods based on rearrangement reactions to obtain novel 2-substituted 3-hydroxy-4-oxo-1,4-dihydroquinolines, an important family of heterocycles with potential applications. Alkyl 3-hydroxy-4-oxo-1,4-dihydroquinoline-2-carboxylates were obtained by alkoxide promoted rearrangement of alkyl isatinacetates. A second synthetic route involves the alkoxide promoted reaction of both isatin and N-methylisatin, with alkylating agents having acidic methylenes. This reaction leads to the formation of spiroepoxyoxindoles via Darzens' condensation. When phenacyl bromides are used, the initially obtained benzoyl substituted spiroepoxyoxindoles were smoothly transformed into the corresponding 2-benzoyl-3-hydroxy-4-quinolinones with good to excellent yields.

USE OF SPIRO-OXINDOLE COMPOUNDS AS THERAPEUTIC AGENTS

This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.