41049-30-3

Basic information

• Product Name: 4-Iodobutyl Tetrahydropyranyl Ether
• Synonyms: 4-Iodobutyl Tetrahydropyranyl Ether;1-Iodo-4-(2-tetrahydropyranyloxy)butane;Tetrahydro-2-(4-iodobutoxy)-2H-pyran
• CAS NO: 41049-30-3
• Molecular Formula: C₉H₁₇IO₂
• Molecular Weight: 284.13455
• Product Categories: Heterocycles;Intermediates;Heterocycles, Intermediates
• Mol File: 41049-30-3.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Iodobutyl Tetrahydropyranyl Ether(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Iodobutyl Tetrahydropyranyl Ether(41049-30-3)
• EPA Substance Registry System: 4-Iodobutyl Tetrahydropyranyl Ether(41049-30-3)

Safety Data

• Hazardous Substances Data: 41049-30-3(Hazardous Substances Data)

Usage

Description

4-Iodobutyl Tetrahydropyranyl Ether is an organic compound characterized by its liquid state. It is a derivative of iodobutane with a tetrahydropyranyl ether functional group, which contributes to its unique chemical properties and potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
4-Iodobutyl Tetrahydropyranyl Ether is used as a key intermediate in the synthesis of indoloylguanidine derivatives. These derivatives serve as Na+/H+ exchanger inhibitors, which play a crucial role in regulating the exchange of sodium and hydrogen ions across cell membranes. This application is particularly relevant in the development of treatments for various diseases and conditions that involve ion imbalance or transport disorders.
The unique chemical structure of 4-Iodobutyl Tetrahydropyranyl Ether allows it to be a valuable component in the creation of these therapeutic agents, making it an important compound in the pharmaceutical industry. Its liquid state also facilitates its use in chemical reactions and synthesis processes, further enhancing its utility in drug development.

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 3210-08-0 4-iodo-butan-1-ol 
• 77416-53-6 1-(methanesulfonoxy)-4-<(tetrahydropyran-2-yl)oxy>butane 
• 41302-05-0 1-chloro-4-tetrahydropyranyloxybutane 
• 51326-51-3 4-(tetrahydropyran-2-yloxy)butan-1-ol 

Downstream Products

• 1720-37-2 2-(hex-5-yn-1-yloxy)tetrahydro-2H-pyran 
• 173986-56-6 diphenyl[4-(tetrahydro-2H-pyran-2-yloxy)butyl]silane 
• 10297-05-9 1-chloro 4-iodobutane 
• 258523-66-9 2-phenyl 2[4(2-tetrahydropyranoxy)butyl] diethyl malonate 
• 90369-06-5 {4-[(tetrahydropyran-2-yl)oxy]butyl}(triphenyl)phosphonium iodide 
• 444682-17-1 (Z)-(2R,3S,4S)-3-(4-methoxybenzyloxy)-2,4-dimethyl-9-(tetrahydropyran-2-yloxy)non-5-enal 
• 623926-34-1 (Z)-(2S,3S,4S)-3-(4-methoxybenzyloxy)-2,4-dimethyl-9-(tetrahydropyran-2-yloxy)non-5-en-1-ol 
• 444682-16-0 (Z)-(2S,3S,4S)-3-(4-methoxybenzyloxy)-2,4-dimethyl-9-(tetrahydropyran-2-yloxy)non-5-en-1-yl tert-butyldimethylsilyl ether 
• 623926-37-4 2-[(Z)-(6S,7S,8R)-9-Iodo-7-(4-methoxy-benzyloxy)-6,8-dimethyl-non-4-enyloxy]-tetrahydro-pyran 
• 623926-53-4 (Z,Z,Z)-(5S,6S,7S,8S,13S,14S,15S)-8,14-bis(4-methoxybenzyloxy)-5,7,13,15-tetramethyl-20-(tetrahydropyran-2-yloxy)eicosa-1,3,11,16-tetraen-6-ol 
• 623926-39-6 (Z,Z,Z)-(5S,6S,7S,8R,13S,14S,15S)-8,14-bis(4-methoxybenzyloxy)-5,7,13,15-tetramethyl-20-(tetrahydropyran-2-yloxy)eicosa-1,3,11,16-tetraen-6-ol 
• 623926-64-7 (3Z,11Z,16Z)-(5S,6S,7S,8R,13S,14S,15S)-6,14-Bis-(4-methoxy-benzyloxy)-5,7,13,15-tetramethyl-20-(tetrahydro-pyran-2-yloxy)-icosa-1,3,11,16-tetraen-8-ol 
• 623926-41-0 Acetic acid (6Z,11Z)-(1S,2S,3R,8S,9S,10S)-3,9-bis-(4-methoxy-benzyloxy)-2,8,10-trimethyl-1-((Z)-(S)-1-methyl-penta-2,4-dienyl)-15-(tetrahydro-pyran-2-yloxy)-pentadeca-6,11-dienyl ester 
• 623926-66-9 Acetic acid (4Z,9Z)-(1R,6S,7S,8S)-7-(4-methoxy-benzyloxy)-1-[(Z)-(1S,2S,3S)-2-(4-methoxy-benzyloxy)-1,3-dimethyl-hepta-4,6-dienyl]-6,8-dimethyl-13-(tetrahydro-pyran-2-yloxy)-trideca-4,9-dienyl ester 

Relevant articles and documents

SYNTHESIS AND STRUCTURAL STUDIES OF BRIDGEHEAD DIENES 3-OXOBICYCLODODECA-1(11),8(9)-DIENE-(ZZ)-11-CARBOXYLIC ACID AND 3-OXOBICYCLOTRIDECA-1(12),9(10)-DIENE-(ZZ)-12-CARBOXYLIC ACID

Single crystal X-ray structures of two bridgehead dienes are reported.The bridgehead double bonds of diene 7 show only modest deviation from strain-free tetrasubstituted double bonds.The double bonds in bridgehead diene 6, however, exhibit an average deviation of the C-C=C-C torsion angle (Φ+Χ) of 14 deg.

Total Synthesis of Phenanthropiperidine Alkaloids by Sequential Alkylation of N,N-Dibenzylaminoacetonitrile

Two representative members of the phenanthropiperidine alkaloid family, tylophorine (1) and cryptopleurine (2), were synthesized by a bidirectional alkylation strategy employing dibenzylaminoacetonitrile as a substrate. This approach relies on the unprecedented condensation of metallated α-aminonitriles with bromomethylphenanthrenes to provide fully substituted α-aminonitriles, which are subjected to a NaBH4-mediated reductive decyanation process to form homobenzylic amines. From these intermediates, a terminal leaving group was introduced by simple chemical manipulation, and its displacement by a free primary amine under two favorable cyclization processes led to the formation of the future E-ring of both alkaloids in high yields. Finally, a late Pictet-Spengler cyclization ensured the formation of a D-ring for the alkaloids 1 and 2.

Spiroacetal biosynthesis in fruit flies is complex: Distinguishable origins of the same major spiroacetal released by different Bactrocera spp.

The major spiroacetal ((E,E)-1) of the pestiferous fruit flies, Bactrocera tryoni and Bactrocera cucumis, is biosynthesised from fatty acids by distinguishable pathways which utilise modified β-oxidation and C-H hydroxylation, generating a putative ketodiol which cyclises. The Royal Society of Chemistry 2010.