41050-95-7Relevant articles and documents
Planarity of heteroaryldithiocarbazic acid derivatives showing tuberculostatic activity: Structure-activity relationships
Szczesio, Ma?gorzata,Go?ka, Jolanta,Korona-G?owniak, Izabela,Orlewska, Czes?awa,Gobis, Katarzyna,Olczak, Andrzej
, p. 400 - 405 (2018)
The search for new tuberculostatics is an important issue due to the increasing resistance of Mycobacterium tuberculosis to existing agents and the resulting spread of the pathogen. Heteroaryldithiocarbazic acid derivatives have shown potential tuberculos
3-pyridyl-3-amino-2-cyanoacrylate compound, and preparation method and application thereof
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Paragraph 0058-0060; 0069-0070, (2019/07/10)
The invention discloses a 3-pyridyl-3-amino-2-cyanoacrylate compound, and a preparation method and application thereof. The structure of the compound is shown in a general formula (1). The preparationmethod of the compound comprises the following steps: taking a compound shown in a formula (II) as a raw material to carry out a reaction with a fatty alcohol in an organic solvent in the presence ofhydrogen chloride to obtain pyridyl imidate, and carrying out a reaction on the pyridyl imidate with cyanoacetate in an organic solvent under catalysis of a catalyst for condensation to prepare the 3-pyridyl-3-amino-2-cyanoacrylate compound. The compound has bactericidal activity and can be used for preventing and treating diseases.
MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF
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Page/Page column 163-164, (2008/12/07)
Provided are compounds that are modulators of C3a receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, the compounds are pyridones. In certain embodiments, provided are methods for treatment or amelioration of diseases associated with modulation of C3a receptor activity.