41051-14-3

Basic information

• Product Name: ethyl 4-ethoxy-3-oxobutyrate
• Synonyms: ethyl 4-ethoxy-3-oxobutyrate;4-Ethoxy-3-oxobutanoic acid ethyl ester;ethyl 4-ethoxy-3-oxobutanoate
• CAS NO: 41051-14-3
• Molecular Formula: C₈H₁₄O₄
• Molecular Weight: 174.19436
• EINECS: 255-187-3
• Mol File: 41051-14-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 243.6°Cat760mmHg
• Flash Point: 100.6°C
• Appearance: /
• Density: 1.039g/cm³
• Vapor Pressure: 0.0318mmHg at 25°C
• Refractive Index: 1.422
• CAS DataBase Reference: ethyl 4-ethoxy-3-oxobutyrate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-ethoxy-3-oxobutyrate(41051-14-3)
• EPA Substance Registry System: ethyl 4-ethoxy-3-oxobutyrate(41051-14-3)

Safety Data

• Hazardous Substances Data: 41051-14-3(Hazardous Substances Data)

Usage

Description

Ethyl 4-ethoxy-3-oxobutyrate is a colorless liquid chemical compound with the molecular formula C8H14O4. It is characterized by a fruity odor and is known for its pleasant aroma.

Uses

Used in Food and Beverage Industry:
Ethyl 4-ethoxy-3-oxobutyrate is used as a flavoring agent for enhancing the taste and aroma of various food and beverage products.
Used in Fragrance Industry:
It is used in the production of fragrances due to its appealing scent, contributing to the creation of perfumes and other scented products.
Used in Cosmetic Products:
Ethyl 4-ethoxy-3-oxobutyrate is utilized in cosmetic products for its pleasant aroma, making it a valuable component in the formulation of scented cosmetics.
Used as a Solvent in Industrial Processes:
ethyl 4-ethoxy-3-oxobutyrate also serves as a solvent in various industrial applications, aiding in the manufacturing process of different products.
Safety Precautions:
It is important to handle ethyl 4-ethoxy-3-oxobutyrate with care, as it can be flammable and potentially harmful if ingested, inhaled, or absorbed through the skin.

InChI:InChI=1/C8H14O4/c1-3-11-6-7(9)5-8(10)12-4-2/h3-6H2,1-2H3

Upstream product

• 817-95-8 ethyl 2-ethoxyethanoate 
• 141-78-6 ethyl acetate 
• 105-36-2 ethyl bromoacetate 
• 13176-46-0 4-bromoethyl acetoacetate 
• 141-52-6 sodium ethanolate 
• 64-17-5 ethanol 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 627-03-2 3-oxapentanoic acid 
• 6148-64-7 ethyl potassium malonate 
• 7732-18-5 water 

Downstream Products

• 861346-22-7 4-ethoxy-2-benzyl-acetoacetic acid ethyl ester 
• 861612-07-9 4-ethoxy-2,2-dibenzyl-acetoacetic acid ethyl ester 
• 71027-66-2 2-Ethoxymethyl-4,6-dihydroxy-benzoic acid ethyl ester 
• 82831-19-4 5-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxylic acid ethyl ester 
• 55551-44-5 2-ethoxymethyl-6-methyl-4-(3'-fluoro-4'-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 
• 55551-43-4 2-ethoxymethyl-6-methyl-4-(2'-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 
• 55551-46-7 2-ethoxymethyl-6-methyl-4-(2'-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 
• 55551-42-3 2-ethoxymethyl-6-methyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 
• 55551-41-2 2-ethoxymethyl-6-methyl-4-(3'-iodophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 
• 55551-40-1 2-ethoxymethyl-6-methyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 
• 1073483-78-9 ethyl 2-(ethoxymethyl)-5-phenyl-1H-pyrrole-3-carboxylate 
• 14869-36-4 1-ethoxy-2-pentanone 

Relevant articles and documents

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NOVEL PROCESS FOR THE PREPARATION OF DOLUTEGRAVIR AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

The present invention relates to a novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof using novel intermediates.

Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ET(A) receptor selectivity

Endothelins, ET-1, ET-2, and ET-3 are potent vasoconstricting and mitogenic 21-amino acid bicyclic peptides, which exert their effects upon binding to the ET(A) and ET(B) receptors. The ET(A) receptor mediates vasoconstriction and smooth muscle cell proliferation, and the ET(B) receptor mediates different effects in different tissues, including nitric oxide release from endothelial cells, and vasoconstriction in certain vascular cell types. Selective antagonists of endothelin receptor subtypes may prove useful in determining the role of endothelin in various tissue types and disease states, and hence as therapeutic agents for such diseases. The pyrrolidine carboxylic acid A-127722 has been disclosed as a potent and ET(A)-selective antagonist, and is currently undergoing clinical trials. In our efforts to find antagonists with altered selectivity (ET(A)-selective, ET(B)-selective, or nonselective), we investigated the SAR of the 2-substituent on the pyrrolidine. Compounds with alkyl groups at the 2-position possessed ET(A) selectivity improved over A-127722 (1400-fold selective), with the best of these compounds showing nearly 19,000-fold selectivity. Copyright (C) 1999 Elsevier Science Ltd.