41107-56-6 Usage
Description
2',3'-DIDEOXY-3'-FLUOROURIDINE, also known as 3′-fluoro-2′,3′-dideoxyuridine (FddUrd), is a fluorinated pyrimidine nucleoside analog of uridine. It is an off-white solid that has been extensively studied for its potential use as an antiviral agent against HIV.
Uses
Used in Antiviral Applications:
2',3'-DIDEOXY-3'-FLUOROURIDINE is used as an antiviral agent for its potential activity against HIV. It serves as a reactant in the synthesis of 5'-trityl nucleosides, which act as inhibitors of Plasmodium falciparum dUTPase, a key enzyme in the DNA synthesis of the parasite responsible for malaria.
Used in Pharmaceutical Industry:
2',3'-DIDEOXY-3'-FLUOROURIDINE is used as a starting material in the synthesis of 3′-fluoro 2′,3′-dideoxynucleoside analogs for in vitro antiviral activity studies. These analogs are crucial in the development of new antiviral drugs to combat various viral infections.
Used in Parasitology Research:
In the field of parasitology, 2',3'-DIDEOXY-3'-FLUOROURIDINE is used as a starting material for the synthesis of 3′-fluoro deoxyuridine monophosphate analogs. These analogs have potential applications as anti-parasitic agents, particularly against parasites that cause diseases such as malaria and other related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 41107-56-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,1,0 and 7 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 41107-56:
(7*4)+(6*1)+(5*1)+(4*0)+(3*7)+(2*5)+(1*6)=76
76 % 10 = 6
So 41107-56-6 is a valid CAS Registry Number.
41107-56-6Relevant articles and documents
Synthesis of 3′-Deoxy-3′-fluoro and -3′-amino Nucleosides from 2-Methylthiopyrimidin-4(1H)-ones
Zahran,Abdel-Megied,Abdel-Rahman,Sofan,Nielsen,Pedersen
, p. 979 - 988 (2007/10/03)
Methyl 2,3-dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-β-D-erythro-pentofuranoside (3) as well as 1,5-di-O-acetyl-2,3-dideoxy-3-phthalimodo-β-D-erythro-pentofuranose (12) were condensed with silylated 2-methylthiopyridin-4(1H)-ones 2a, b in the presence of trimethylsilyl triflate as a catalyst to produce the corresponding nucleosides 5, 6, 13. In these reactions, an endocyclic cleavage of C-O in 3 took place; therefore, acyclic nucleosides 4a, b were also formed. All 3′-fluoro nucleosides were deprotected with NH3/MeOH; the 3′-phthalimido nucleosides were deprotected with methylamine in ethanol. The latter method resulted in a concomitant substitution reaction in the pyrimidine moiety with replacement of the methylthio group. The 2-methylthio analogue of 3′-deoxy-3′-fluorothylmidine showed moderate activity against HIV-1.
