41126-22-1

Basic information

• Product Name: 1-(2-methoxyphenyl)-3-phenyl-propane-1,3-dione
• Synonyms: 1-(2-methoxyphenyl)-3-phenyl-propane-1,3-dione
• CAS NO: 41126-22-1
• Molecular Formula: C₁₆H₁₄O₃
• Molecular Weight: 254.28
• Mol File: 41126-22-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 65 °C
• Boiling Point: 424.7°Cat760mmHg
• Flash Point: 189.6°C
• Appearance: /
• Density: 1.151g/cm³
• Vapor Pressure: 2.02E-07mmHg at 25°C
• Refractive Index: 1.57
• PKA: 9.34±0.33(Predicted)
• CAS DataBase Reference: 1-(2-methoxyphenyl)-3-phenyl-propane-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methoxyphenyl)-3-phenyl-propane-1,3-dione(41126-22-1)
• EPA Substance Registry System: 1-(2-methoxyphenyl)-3-phenyl-propane-1,3-dione(41126-22-1)

Safety Data

• Hazardous Substances Data: 41126-22-1(Hazardous Substances Data)

Usage

Source

Turmeric plant

Color

Bright yellow

Biological Properties

Anti-inflammatory
Antioxidant
Anticancer

Potential Medicinal Uses

Arthritis treatment
Cancer treatment
Alzheimer's disease treatment

Other Uses

Food additive and coloring agent (turmeric extract)

Bioavailability

Low (poorly absorbed by the body)

InChI:InChI=1/C16H14O3/c1-19-16-10-6-5-9-13(16)15(18)11-14(17)12-7-3-2-4-8-12/h2-10H,11H2,1H3

Upstream product

• 7335-26-4 ethyl 2-methoxybenzoate 
• 98-86-2 acetophenone 
• 93-58-3 benzoic acid methyl ester 
• 579-74-8 2-Methoxyacetophenone 
• 93-89-0 benzoic acid ethyl ester 
• 31949-21-0 bromomethyl 2-methoxyphenyl ketone 
• 63468-90-6 phenylglyoxylic acid potassium salt 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 16619-66-2 1-(2-methoxyphenyl)-3-phenylprop-2-yn-1-one 
• 932-90-1 Benzaldoxime 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 579-75-9 2-Methoxybenzoic acid 
• 65-85-0 benzoic acid 
• 130824-65-6 (Z)-2,7-Dimethoxychalcone 
• 130824-66-7 (Z)-2',7-Dimethoxychalcone 
• 116625-78-6 (2-Methoxy-phenyl)-(2-phenyl-[1,8]naphthyridin-3-yl)-methanone 
• 72195-28-9 2-(2'-methoxyphenyl)-1,8-naphthyridine 
• 126516-71-0 1-(2-Methoxy-phenyl)-2,2-dimethyl-3-phenyl-propane-1,3-dione 
• 53543-10-5 Benzoyl-(2-methoxybenzoyl)-keten-S,S-dimethylacetal 
• 6948-61-4 (E)-1-(2-methoxyphenyl)-3-phenylprop-2-en-1-one 
• 22965-99-7 (E)-3-(2-methoxylphenyl)-1-phenylprop-2-en-1-one 
• 130824-70-3 1-((E)-3,3-Dimethoxy-3-phenyl-propenyl)-2-methoxy-benzene 
• 130824-68-9 1-((E)-1,1-Dimethoxy-3-phenyl-allyl)-2-methoxy-benzene 
• 130824-72-5 1-((E)-3-Ethoxy-3-methoxy-3-phenyl-propenyl)-2-methoxy-benzene 
• 130824-69-0 (E)-2,7-Dimethoxychalcone 

Relevant articles and documents

Metal-Free, DBU-Mediated, Microwave-Assisted Synthesis of Benzo[c]xanthones by Tandem Reactions of Alkynyl-1,3-diketones

A base-mediated, green, microwave-assisted efficient preparation of a diverse benzoxanthone library from variety of readily accessible γ-alkynyl 1,3-diketones is reported. The synthesis is based on tandem reactions involving intramolecular cyclization, propargyl-allenyl isomerization, and electrocyclization in one pot. Some of the benzoxanthones are also synthesized by the one-pot reaction of 1,3-diketone and alkynyl bromide under basic heating conditions. This transformation also results in the construction of one new C?C bond and one new C?O bond. (Figure presented.).

An effective preparation of both 1,3-diketones and nitriles from alkynones with oximes as hydroxide sources

An effective phosphine-catalyzed protocol has been established for the syntheses of 1,3-diketones and nitriles from alkynones with oximes as hydroxide surrogates. This method features the use of a phosphine catalyst, compatibility with various functional groups and ambient temperature, which makes this approach very practical. A plausible mechanism was proposed.

Transition-metal-free formal decarboxylative coupling of ?±-oxocarboxylates with ?±-bromoketones under neutral conditions: A simple access to 1,3-diketones

A transition-metal-free formal decarboxylative coupling reaction between ?±-oxocarboxylates and ?±-bromoketones to synthesize 1,3-diketone derivatives is presented. In this reaction, a broad scope of substrates can be employed, and neither a metal-based reagent nor an additional base is required. DFT calculations reveal that this reaction proceeds through a coupling followed by decarboxylation mechanism and the ?±-bromoketone unprecedentedly serves as a nucleophile under neutral conditions. The rate-determining step is an unusual hydrogen-bond-assisted enolate formation by thermolysis.