41177-72-4

Basic information

• Product Name: 5-BROMO-2,3-DIHYDROBENZOFURAN-7-CARBOXYLIC ACID
• Synonyms: Bromodihydrobenzofurancarboxylicacid;5-BROMO-2,3-DIHYDROBENZOFURAN-7-CARBOXYLIC ACID 97+%;5-Bromo-2,3-dihydrobenzo[b]furan-7-carboxylic acid, May contain varying amounts of anhydride, 97%;5-bromo-2,3-dihydro-1-benzofuran-7-carboxylic acid;5-BroMo-2,3-dihydrobenzo[b]furan-7-carboxylic acid, 97%, Variable anhydride content;7-Benzofurancarboxylic acid, 5-bromo-2,3-dihydro-;5-BROMOCOUMARAN-7-CARBOXYLIC ACID;5-BROMO-2,3-DIHYDROBENZO[B]FURAN-7-CARBOXYLIC ACID
• CAS NO: 41177-72-4
• Molecular Formula: C₉H₇BrO₃
• Molecular Weight: 243.05
• EINECS: 604-604-1
• Product Categories: Benzodiozoles, Benzodioxines & Benzodioxepines;Carboxylic Acids;Benzodiozoles, Benzodioxines & Benzodioxepines;Carboxylic Acids
• Mol File: 41177-72-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 230 °C
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-BROMO-2,3-DIHYDROBENZOFURAN-7-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2,3-DIHYDROBENZOFURAN-7-CARBOXYLIC ACID(41177-72-4)
• EPA Substance Registry System: 5-BROMO-2,3-DIHYDROBENZOFURAN-7-CARBOXYLIC ACID(41177-72-4)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-51-22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 41177-72-4(Hazardous Substances Data)

Usage

General Description

5-Bromo-2,3-dihydrobenzofuran-7-carboxylic acid is an organic compound containing a carboxylic acid functional group and a bromine atom attached to a dihydrobenzofuran ring. It is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its potential as a building block for various bioactive compounds. This chemical also exhibits potential antifungal and antibacterial properties, making it a promising candidate for the development of new drugs. Additionally, it has been studied for its potential use as a fluorescence probe in biological and environmental monitoring. Overall, 5-Bromo-2,3-dihydrobenzofuran-7-carboxylic acid is a versatile and valuable chemical with various potential applications in the fields of medicine, agriculture, and environmental science.

Upstream product

• 124-38-9 carbon dioxide 
• 123266-59-1 5,7-Dibromo-2,3-dihydrobenzofuran 
• 35700-40-4 2,3-dihydrobenzofuran-7-carboxylic acid 
• 496-16-2 2.3-dihydrobenzofuran 

Downstream Products

• 149109-10-4 ethyl 5-bromo-2,3-dihydro-1-benzofuran-7-carboxylate 
• 108551-60-6 5-bromo-7-carboxy-2,3-dihydrobenzofuran chloride 
• 108551-59-3 7-carboxy-5-ethyl-2,3-dihydrobenzofuran 
• 123266-61-5 5-iodo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,3-dihydrobenzofurancarboxamide 
• 252921-20-3 5-bromo-2,3-dihydro-benzofuran-7-carboxylic acid methyl ester 
• 1426845-16-0 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-7'-(oxazolo[4,5-b]pyridin-2-yl)-[5,5'-bibenzofuran]-3-carboxamide 
• 1422205-95-5 ethyl 5-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-2,3-dihydro-1-benzofuran-7-carboxylate 
• 1422205-96-6 5-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-2,3-dihydro-1-benzofuran-7-carboxylic acid 

Relevant articles and documents

Methods for cancer imaging and therapy using benzamine compounds

The present invention relates to a class of compounds having affinity for certain cancer cells, e.g. lung carcinomas, colon carcinomas, renal carcinomas, prostate carcinomas, breast carcinomas, malignant melanomas, gliomas, neuroblastomas and pheochromocy

Carboxamides useful as antiemetic or antipsychotic agents

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Synthesis and characterization of iodobenzamide analogues: Potential D-2 dopamine receptor imaging agents

(S)-N-[(1-Ethyl-2-pyrrolidinyl)methyl]-2-hydroxy-3-iodo-6-methoxybenza mide ([123I]IBZM) is a central nervous system (CNS) D-2 dopamine receptor imaging agent. In order to investigate the versatility of this parent structure in specific dopamine receptor localization and the potential for developing new dopamine receptor imaging agents, a series of new iodinated benzamides with fused ring systems, naphthalene (INAP) and benzofuran (IBF), was synthesized and radiolabeled, and the in vivo and in vitro biological properties were characterized. The best analogue of IBZM is IBF (21). The specific binding of [125I]IBF (21) with rat striatal tissue preparation was found to be saturable and displayed a K(d) of 0.106 ± 0.015 nM. Competition data of various receptor ligands (for [125I]IBF (21) binding show the following rank order of potency: spiperone > IBF (21) > IBZM > (+)-butaclamol > (±)-ADTN,6,7 > ketanserin > SCH-23390 >> propranolol. The in vivo biodistribution results confirm that [125I]IBF (21) concentrated in the striatal area after iv injection into rats. The study demonstrates that [123I]IBF (21) is a potential agent for imaging CNS D-2 dopamine receptors.