41187-40-0Relevant articles and documents
One-pot and catalyst-free synthesis of pyrroloquinolinediones and quinolinedicarboxylates
Zhang, Xiaofeng,Dhawan, Gagan,Muthengi, Alex,Liu, Shuai,Wang, Wei,Legris, Marc,Zhang, Wei
, p. 3851 - 3855 (2017)
A method for the catalyst-free synthesis of pyrroloquinolinediones and quinolinedicarboxylates is developed through a one-pot synthesis involving denitrogenation of azide, benzisoxazole formation, aza-Diels-Alder cycloaddition, and dehydrative aromatization. Only stoichiometric amounts of N2 and H2O are produced as by-products. A comprehensive green chemistry metrics analysis indicated that this method is much more efficient and greener than two reported methods for the synthesis of pyrroloquinolinediones.