41198-42-9

Basic information

• Product Name: 3-(1-Naphthalenyloxy)propiophenone
• Synonyms: 3-(1-Naphthalenyloxy)propiophenone;3-(1-Naphthalenyloxy)-1-phenyl-1-propanone;3-(1-Naphthyloxy)propiophenone;Dapoxetine Impurity 8
• CAS NO: 41198-42-9
• Molecular Formula: C₁₉H₁₆O₂
• Molecular Weight: 276.32914
• Product Categories: Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 41198-42-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Very Slightly, Heated)
• CAS DataBase Reference: 3-(1-Naphthalenyloxy)propiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-Naphthalenyloxy)propiophenone(41198-42-9)
• EPA Substance Registry System: 3-(1-Naphthalenyloxy)propiophenone(41198-42-9)

Safety Data

• Hazardous Substances Data: 41198-42-9(Hazardous Substances Data)

Usage

Description

3-(1-Naphthalenyloxy)propiophenone is an organic compound that is identified as an impurity in the pharmaceutical drug Dapoxetine (D185700). It is characterized by its molecular structure, which includes a naphthalene ring and a propiophenone group, contributing to its specific properties and potential applications.

Uses

Used in Pharmaceutical Industry:
3-(1-Naphthalenyloxy)propiophenone is used as an impurity in the production of Dapoxetine (D185700) for the pharmaceutical industry. Its presence is significant as it can impact the quality, efficacy, and safety of the final drug product. As an impurity, it is essential to monitor and control its levels during the manufacturing process to ensure the drug meets the required standards and specifications.

Upstream product

• 908291-72-5 3-(naphthalen-1-yloxy)-1-phenyl-propan-1-ol 
• 936-59-4 3-chloropropiophenone 
• 90-15-3 α-naphthol 

Downstream Products

• 1071929-03-7 Dapoxetine hydrochloride 
• 908291-72-5 (R)-(-)-3-(1-naphthalenyloxy)-1-phenyl-1-propanol 
• 147199-40-4 Didesmethyldapoxetine 
• 119356-76-2 N,N-dimethylamino-3-(naphthyl-1-oxy)-1-phenylprop-1-amine 
• 119357-34-5 1-phenyl-3-(naphthyl-1-oxy)propylamine 

Relevant articles and documents

Biosynthesis method of dapoxetine intermediate and intermediate thereof (by machine translation)

The method comprises a compound (2) and a compound (3) as starting materials, wherein the compound (4), the compound (4) and the biological enzyme conversion reaction are subjected to biological enzyme conversion reaction to finally obtain the dapoxetine intermediate compound (1), and the reaction formula is as follows: The method has the advantages, such as novel, simple and easy synthesis route, low cost, high synthesis yield, high yield, good product purity, good product quality, cheap and accessible raw materials and suitability for industrial production, and provides a new intermediate raw material for the preparation of dapoxetine intermediate . the synthetic method has the advantages of simple and easy synthesis route, high yield, good product quality, cheap and easily available raw materials and the like. (by machine translation)

Dapoxetine intermediate and preparation method thereof

The invention discloses a dapoxetine intermediate and a preparation method thereof and provides a preparation method for the compound represented in the formula (2). The preparation method includes a step of performing a nucleophilic substitution reaction to the compound represented in the formula (3) with 1-naphthol in a solvent in the presence of alkali to prepare the compound represented in the formula (2). The R1 and the R2 are independently C1-C4 alkyl groups, or that the R1, the R2, oxygen atoms connected thereto respectively and carbon atoms connected to the oxygen atoms form a five-membered saturated ring structure or six-membered saturated ring structure, wherein X is Cl, Br or I. The raw materials are low in cost and easy to obtain. The preparation method is mild in reaction conditions, is high in conversion rate, is high in yield, is simple in after treatment, is low in production cost, is high in chemical purity of product, and is suitable for industrial production.