41206-96-6Relevant articles and documents
Methylation of Quercetin by Diazomethane and Hypoglycemic Activity of its Tetra-O-Methyl Ether
Karimova,Baltina,Spirikhin,Sapozhnikova,Gabdrakhmanova,Makara
, p. 837 - 841 (2020/09/18)
The tetra-O-methyl ether of quercetin (QU) 3 (54%), 3,7,4′-tri-O-methyl ether 4 (30%), and a previously unreported 3,7,3-tri-O-methyl ether of QU 5 (7%) were obtained via methylation of QU by an excess of diazomethane in dioxane. Their structures were established using 2D NMR (1H–1H COSY, 1H–1H NOESY, 1H–13C HSQC, 1H–13C HMBC). Tetra-O-methyl ether of QU 3 exhibited pronounced hypoglycemic activity, reduced alloxan-induced hyperglycemia in rats by 44.5% compared to a control, and was 2.7 times more active than QU.
CHEMICAL CONSTITUTION OF Ledum palustre
Mikhailova, N. S.,Rybalko, K.S.
, p. 131 - 135 (2007/10/02)
From the herb Ledum palustre L., collected in July in Kostroma province we have isolated β-sitosterol, the triterpenoids taraxerol, uvaol, and ursolic acid, the coumarin fraxetin, the known flavonoids quercetin, hyperoside, and 3,3',7-tri-O-methylquerceti