4121-40-8

Basic information

• Product Name: Tenofovir Disoproxil Related Compound B (10 mg) ((E)-9-(Prop-1-enyl)-9H-purin-6-amine)
• Synonyms: Tenofovir Disoproxil Related Compound B (10 mg) ((E)-9-(Prop-1-enyl)-9H-purin-6-amine);9-Propenyladenine;((E)-9-(Prop-1-enyl)-9H-purin-6-aMine);9-Propenyladenine (Tenofovir IMpurity);Tenofovir Disoproxil Related CoMpound B;9-(1-Propenyl)-9H-purin-6-amine;(E)-9-(prop-1-en-1-yl)-9H-purin-6-amine;9-(prop-1-en-1-yl)-9H-purin-6-amine
• CAS NO: 4121-40-8
• Molecular Formula: C₈H₉N₅
• Molecular Weight: 175.19056
• Mol File: 4121-40-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 197℃
• Boiling Point: 415.6±48.0 °C(Predicted)
• Appearance: /
• Density: 1.39±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 4.08±0.10(Predicted)
• CAS DataBase Reference: Tenofovir Disoproxil Related Compound B (10 mg) ((E)-9-(Prop-1-enyl)-9H-purin-6-amine)(CAS DataBase Reference)
• NIST Chemistry Reference: Tenofovir Disoproxil Related Compound B (10 mg) ((E)-9-(Prop-1-enyl)-9H-purin-6-amine)(4121-40-8)
• EPA Substance Registry System: Tenofovir Disoproxil Related Compound B (10 mg) ((E)-9-(Prop-1-enyl)-9H-purin-6-amine)(4121-40-8)

Safety Data

• Hazardous Substances Data: 4121-40-8(Hazardous Substances Data)

Usage

Description

Tenofovir Disoproxil Related Compound B (10 mg) ((E)-9-(Prop-1-enyl)-9H-purin-6-amine) is an N-substituted purine derivative and an impurity associated with Tenofovir (T018500). It is a white to pale yellow solid and is known for its pharmaceutical relevance.

Uses

Used in Pharmaceutical Industry:
Tenofovir Disoproxil Related Compound B (10 mg) ((E)-9-(Prop-1-enyl)-9H-purin-6-amine) is used as an impurity reference for the development and quality control of Tenofovir, an antiviral medication. Its presence is crucial for ensuring the purity and efficacy of the final drug product, as it helps in monitoring and controlling the synthesis process of Tenofovir.
Used in Research and Development:
In the field of research and development, Tenofovir Disoproxil Related Compound B (10 mg) ((E)-9-(Prop-1-enyl)-9H-purin-6-amine) serves as a valuable compound for studying the properties and behavior of N-substituted purines. This can lead to advancements in the understanding of their potential applications in medicinal chemistry and drug discovery.

Upstream product

• 1530-32-1 ethyltriphenylphosphonium bromide 
• 6034-68-0 N⁶-acetyladenine 

Downstream Products

• 14047-28-0 (R)-9-(2-hydroxypropyl)adenine 
• 14047-27-9 (S)-1-(6-amino-9H-purin-9-yl) propan-2-ol 

Relevant articles and documents

A method of synthesis for fuwei intermediates (by machine translation)

The invention discloses a method for synthesizing for fuwei intermediate of the method, the method comprises: formula 2 compound of formula 9 - propenyl adenine as raw materials, in the (S)- (-) - 2, 2 '- double (b benzene phosphine base) - 1, 1' - binaphthyl induction, and tetramethyl piperidine nitrogen oxide oxidation reaction to obtain the type 1 indicated by the tenofovir intermediate (R)- 9 - (2 - hydroxy-propyl) adenine; Through the method of the invention for the preparation of tenofovir intermediate (R)- 9 - (2 - hydroxy-propyl) adenine, mild reaction conditions, the industrial application and popularization; yield of the object product, good selectivity; without using a large amount of chiral compounds, the use of a small amount of chiral auxiliary can be induced oxidation, the cost is low. (by machine translation)