412278-24-1

Basic information

• Product Name: Carbamic acid, [(3S,4R)-tetrahydro-4-hydroxy-3-furanyl]-, 1,1-dimethylethyl
• Synonyms: Carbamic acid, [(3S,4R)-tetrahydro-4-hydroxy-3-furanyl]-, 1,1-dimethylethyl;Trans-3-N-Boc-3-aMino-4-hydroxy-tetrahydrofuran;Tert-Butyl (3S,4R)-4-Hydroxytetrahydrofuran-3-Ylcarbamate;Tert-Butyl (3S,4R)-4-Hydroxytetrahydrofuran-3-Ylcarbamate(WX641105)
• CAS NO: 412278-24-1
• Molecular Formula: C9H17NO4
• Molecular Weight: 203.23558
• Product Categories: N-BOC
• Mol File: 412278-24-1.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, [(3S,4R)-tetrahydro-4-hydroxy-3-furanyl]-, 1,1-dimethylethyl(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(3S,4R)-tetrahydro-4-hydroxy-3-furanyl]-, 1,1-dimethylethyl(412278-24-1)
• EPA Substance Registry System: Carbamic acid, [(3S,4R)-tetrahydro-4-hydroxy-3-furanyl]-, 1,1-dimethylethyl(412278-24-1)

Safety Data

• Hazardous Substances Data: 412278-24-1(Hazardous Substances Data)

Usage

General Description

Carbamic acid, [(3S,4R)-tetrahydro-4-hydroxy-3-furanyl]-, 1,1-dimethylethyl is a chemical compound with the molecular formula C8H15NO3. It is also known as tBu-Carbamic acid and is used in the production of pharmaceuticals due to its ability to act as a protecting group for amines in organic synthesis. Carbamic acid, [(3S,4R)-tetrahydro-4-hydroxy-3-furanyl]-, 1,1-dimethylethyl is a derivative of carbamic acid and its structure includes a tetrahydro-4-hydroxy-3-furanyl group and a 1,1-dimethylethyl group. It is important to handle this chemical with care and follow safety protocols when working with it in a laboratory setting.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 153610-13-0 (3S,4R)-4-Azido-tetrahydro-furan-3-ol 
• 1708-29-8 2,5-dihydrofuran 
• 4248-19-5 tert-butyl carbazate 
• 144870-96-2 trans-4-amino-3-hydroxytetrahydrofuran 
• 190792-70-2 (3R,4S)-4-aminotetrahydrofuran-3-ol 
• 1430230-65-1 (±)-cis-3-tert-butoxycarbonylamino-4-hydroxytetrahydrofuran 
• 103-80-0 phenylacetyl chloride 
• 144870-96-2 4-amino-3-hydroxytetrahydrofuran 

Downstream Products

• 1414975-77-1 tert-butyl N-(4-oxotetrahydrofuran-3-yl)carbamate 
• 1629586-23-7 tert-butyl ((3R,4S)-4-aminotetrahydrofuran-3-yl)carbamate 
• 153610-11-8 (3S,4S)-3-amino-4-hydroxytetrahydrofuran 
• 1430230-65-1 (3S,4S)-3-tert-butoxycarbonylamino-4-hydroxytetrahydrofuran 
• 153610-11-8 (3R,4R)-3-amino-4-hydroxy-tetrahydrofuran 
• 1629586-23-7 tert-butyl ((3S,4S)-4-aminotetrahydrofuran-3-yl)carbamate 
• 1629586-23-7 tert-butyl rac-cis-N-(4-aminotetrahydrofuran-3-yl)carbamate 

Relevant articles and documents

SALT FORM AND CRYSTAL FORM OF COMPOUND AS FGFR4 INHIBITOR AND PREPARATION METHOD THEREOF

The present invention provides a salt form, a crystal form, and a preparation method of a compound as an FGFR4 inhibitor and medical uses thereof.

FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF

Provided are an FGFR4 inhibitor having the structure of formula (I), and a preparation method therefor and the use thereof. The compound has a very strong inhibitory effect on FGFR4 kinase activity and has a very high selectivity, and can be widely used in the preparation of a drug for treating cancers, especially prostate cancer, liver cancer, pancreatic cancer, esophageal carcinomas, gastric cancer, lung cancer, breast cancer, ovarian carcinomas, colon cancer, skin cancer, glioblastomas or rhabdomyosarcomas, and is expected to be developed into a new generation of FGFR4 inhibitor drugs.

Scalable Syntheses of Chirally Pure Mono-protected and Orthogonally Di-protected cis -3,4-Diaminotetrahydrofurans

Scalable and chromatography-free syntheses of chirally pure and orthogonally protected cis -3,4-diaminotetrahydrofurans prepared from a single starting material, 3,4-epoxytetrahydrofuran, are presented..