412296-10-7

Basic information

• Product Name: (R)-2-(4-chlorophenyl)-2-(trimethylsiloxy)acetonitrile
• Synonyms: (R)-2-(4-chlorophenyl)-2-(trimethylsiloxy)acetonitrile
• CAS NO: 412296-10-7
• Molecular Weight: 239.777
• Mol File: 412296-10-7.mol
• Article Data: 31

Chemical Properties

• CAS DataBase Reference: (R)-2-(4-chlorophenyl)-2-(trimethylsiloxy)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(4-chlorophenyl)-2-(trimethylsiloxy)acetonitrile(412296-10-7)
• EPA Substance Registry System: (R)-2-(4-chlorophenyl)-2-(trimethylsiloxy)acetonitrile(412296-10-7)

Safety Data

• Hazardous Substances Data: 412296-10-7(Hazardous Substances Data)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 873-76-7 para-Chlorobenzyl alcohol 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 126641-86-9 (R)-acetoxy(4-chlorophenyl)acetonitrile 
• 13312-83-9 (R)-(+)-4-chloromandelonitrile 

Relevant articles and documents

Straightforward access to high-performance organometallic catalysts by fluoride activation: Proof of principle on asymmetric cyanation, asymmetric Michael addition, CO2 addition to epoxide, and reductive alkylation of amines by tetrahydrofuran

We demonstrate that well-known transition metal catalysts can be transformed into high-performance versions by the simple use of a fluoride anion source. In situ fluoride-activated catalysts are highly active catalytic species. The isolation may lead to degradation of the species or a decrease in catalytic activity. Fluoride activation of known, relatively simple catalysts resulted in the development of one of the most efficient catalytic systems for the asymmetric cyanation of aldehydes, asymmetric Michael addition, and synthesis of cyclic carbonates. Furthermore, the fluoride-assisted reductive opening of tetrahydrofuran (THF) with amines was developed. We believe that the proposed approach can find broad applications in the enhancement of known catalytic processes and in the design of new ones.

Chiral Metal-Organic Framework Decorated with TEMPO Radicals for Sequential Oxidation/Asymmetric Cyanation Catalysis

A chiral porous metal-organic framework (MOF) decorated with radicals has been successfully constructed by cocrystallizing achiral (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO)-substituted tricarboxylate and enantiopure VO(salen)-derived dipyridine ligands. The chiral MOF can function as an efficient heterogeneous catalyst for the sequential alcohol oxidation/asymmetric cyanation of aldehyde reactions with enhanced activity and enantioselectivity compared to the homogeneous counterpart.

A homochiral vanadium-salen based cadmium bpdc MOF with permanent porosity as an asymmetric catalyst in solvent-free cyanosilylation

A homochiral vanadium-salen based MOF with the pcu topology is constructed via in situ synthesis under solvothermal conditions. The synthesized MOF exhibits BET surface areas of 574 m2 g-1, showing the highest H2 adsorptio