412298-86-3

Basic information

• Product Name: (5,5-DIMETHYL-2-OXO-TETRAHYDRO-FURAN-3-YL)-ACETIC ACID
• Synonyms: (5,5-DIMETHYL-2-OXO-TETRAHYDRO-FURAN-3-YL)-ACETIC ACID;Zinc00178389;Zinc00178391;(5,5-Dimethyl-2-oxotetrahydro-3-furanyl)acetic acid
• CAS NO: 412298-86-3
• Molecular Formula: C8H12O4
• Molecular Weight: 172.18
• Mol File: 412298-86-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 362.7°Cat760mmHg
• Flash Point: 150.9°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 3E-06mmHg at 25°C
• Refractive Index: 1.462
• CAS DataBase Reference: (5,5-DIMETHYL-2-OXO-TETRAHYDRO-FURAN-3-YL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (5,5-DIMETHYL-2-OXO-TETRAHYDRO-FURAN-3-YL)-ACETIC ACID(412298-86-3)
• EPA Substance Registry System: (5,5-DIMETHYL-2-OXO-TETRAHYDRO-FURAN-3-YL)-ACETIC ACID(412298-86-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 412298-86-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 5977, 1955 DOI: 10.1021/ja01627a055

InChI:InChI=1/C8H12O4/c1-8(2)4-5(3-6(9)10)7(11)12-8/h5H,3-4H2,1-2H3,(H,9,10)

Upstream product

• 7647-01-0 hydrogenchloride 
• 18908-20-8 2-methyl-2-propen-1-yl succinic anhydride 
• 7647-18-9 antimonypentachloride 
• 71-43-2 benzene 
• 132631-34-6 isobutylidene-succinic acid 
• 479546-49-1 2-ethoxycarbonyl-2-ethoxycarbonylmethyl-4-methylpentanolide 
• 14668-39-4 ethyl 5,5-dimethyl-2-oxotetrahydrofuran-3-carboxylate 
• 97-65-4 2-methylenesuccinic acid 
• 67-63-0 isopropyl alcohol 

Relevant articles and documents

Synthesis of new carboxy lactones and some their transformations

Alkylation of 2-ethoxycarbonyl-4-pentanolides with ethyl chloroacetate gave 2-ethoxycarbonyl-2-ethoxycarbonylmethyl-4-pentanolides. Alkaline hydrolysis of the latter afforded 2-carboxymethyl-4-pentanolides which were converted into the corresponding acyl chlorides in high yield by treatment with thionyl chloride in the presence of a catalytic amount of dimethylformamide. Reaction of 2-chloroformylmethyl-4-pentanolides with thiosemicarbazide, followed by treatment with alkali, resulted in formation of 2-(5-mercapto-1,2,4-triazol-3-ylmethyl)-4-pentanolides.