41230-20-0

Basic information

• Product Name: 2-Benzo[1,3]dioxol-5-yl-benzothiazole
• Synonyms: 2-Benzo[1,3]dioxol-5-yl-benzothiazole
• CAS NO: 41230-20-0
• Molecular Formula: C14H9NO2S
• Molecular Weight: 255.29
• Mol File: 41230-20-0.mol
• Article Data: 26

Chemical Properties

• Melting Point: 125 °C
• Boiling Point: 415.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.397±0.06 g/cm3(Predicted)
• PKA: 0.86±0.10(Predicted)
• CAS DataBase Reference: 2-Benzo[1,3]dioxol-5-yl-benzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzo[1,3]dioxol-5-yl-benzothiazole(41230-20-0)
• EPA Substance Registry System: 2-Benzo[1,3]dioxol-5-yl-benzothiazole(41230-20-0)

Safety Data

• Hazardous Substances Data: 41230-20-0(Hazardous Substances Data)

Usage

Chemical Structure

It is a benzothiazole derivative.
It has a benzo[1,3]dioxole group attached at the 2-position.

Potential Therapeutic Agent

Studied for medicinal chemistry applications.

Pharmacological Activities

Being investigated as an antifungal and antibacterial agent.

Fluorescence Probe

Shows potential as a fluorescence probe in biochemical and pharmaceutical research.

Research Needs

Further research required to fully understand its properties and potential applications.

Upstream product

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• 1155-00-6 bis(2-nitrophenyl)disulfide 
• 4421-09-4 piperonylonitrile 
• 137-07-5 2-amino-benzenethiol 
• 1141-88-4 2-Aminophenyl disulfide 
• 1239970-42-3 C₂₈H₂₀N₂O₄S₂ 
• 49711-55-9 (E)-3-(benzo[d][1,3]dioxol-5-yl)-2-cyanoacrylic acid 
• 495-76-1 piperonol 
• 615-43-0 2-iodophenylamine 
• 2620-50-0 1,3-benzodioxol-5-ylmethyl amine 
• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 

Relevant articles and documents

Benzothiazole Synthesis: Mechanistic Investigation of an in Situ-Generated Photosensitizing Disulfide

The use of a visible light absorbing intermediate as a photosensitizer makes a chemical process simple and sustainable, obviating the need for the use of chemical additives. Herein, the formation of a photosensitizing disulfide in benzothiazole synthesis from 2-Aminothiophenol and aldehydes was proposed and confirmed through in-depth mechanistic studies. A series of photophysical and electrochemical investigations revealed that an in situ-generated disulfide photosensitizes molecular oxygen to generate the key oxidants, singlet oxygen and superoxide anion, for the dehydrogenation step.

Selective Construction of 2-Substituted Benzothiazoles from o-Iodoaniline Derivatives S8 and N-Tosylhydrazones

Selective construction of 2-substituted benzothiazoles from o-iodoaniline derivatives S8 and N-tosylhydrazone via a copper-promoted [3 + 1 + 1]-type cyclization reaction has been realized. In the protocol, the carbon atom on N-tosylhydrazone could be regulated to construct benzothiazole by changing the reaction system. Furthermore, the transformation has achieved the construction of multiple carbon-heteroatom bonds.

Iron(II) bromide-catalyzed oxidative coupling of benzylamines with ortho-substituted anilines: Synthesis of 1,3-benzazoles

An iron(II) bromide-catalyzed oxidative coupling of benzylamines with 2-amino/hydroxy/mercapto-anilines has been developed, allowing the synthesis of a diversity of substituted 1,3-benzazoles in good to excellent yields. This transformation is compatible with a wide range of functional groups. The method is practical, economical and employs molecular oxygen as an oxidant.