412345-84-7Relevant articles and documents
Synthesis and in vitro evaluation of ambrisentan analogues as potential endothelin receptor antagonists
Xia, Jun,Song, Jianfei,Zhen, Le,Zhang, Xiuling,Lei, Xiantao,Zheng, Lina,Wang, Qiujuan,Sun, Hongbin
, p. 3894 - 3897 (2011/08/06)
A series of novel 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl butyric acid derivatives were synthesized and evaluated for their antagonistic activity for endothelin-1-induced contraction in rabbit aorta. Within this series of compounds, 2-[(4,6-dimet