41240-81-7

Basic information

• Product Name: 2-chloro-N-(4-propoxy-phenyl)-acetamide
• CAS NO: 41240-81-7
• Molecular Weight: 227.691
• Mol File: 41240-81-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-(4-propoxy-phenyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-(4-propoxy-phenyl)-acetamide(41240-81-7)
• EPA Substance Registry System: 2-chloro-N-(4-propoxy-phenyl)-acetamide(41240-81-7)

Safety Data

• Hazardous Substances Data: 41240-81-7(Hazardous Substances Data)

Upstream product

• 4469-80-1 4-propoxyaniline 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 50824-56-1 N,N-diethyl-glycine-(4-propoxy-anilide) 

Relevant articles and documents

Novel selective ido1 inhibitors with isoxazolo[5,4-d]pyrimidin-4(5h)-one scaffold

Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising target in immunomodulation of several pathological conditions, especially cancers. Here we present the synthesis of a series of IDO1 inhibitors with the novel isoxazolo[5,4-d]pyrimidin-4(5H)-one scaffold. A focused library was prepared using a 6-or 7-step synthetic procedure to allow a systematic investigation of the structure-activity relationships of the described scaffold. Chemistry-driven modifications lead us to the discovery of our best-in-class inhibitors possessing p-trifluoromethyl (23), p-cyclohexyl (32), or p-methoxycarbonyl (20, 39) substituted aniline moieties with IC50 values in the low micromolar range. In addition to hIDO1, compounds were tested for their inhibition of indoleamine 2,3-dioxygenase 2 and tryptophan dioxygenase, and found to be selective for hIDO1. Our results thus demon-strate a successful study on IDO1-selective isoxazolo[5,4-d]pyrimidin-4(5H)-one inhibitors, defining promising chemical probes with a novel scaffold for further development of potent small-molecule immunomodulators.