41252-83-9

Basic information

• Product Name: 2-Phenyl-2-bromoethanol
• Synonyms: 2-Bromo-2-phenylethanol;2-Phenyl-2-bromoethanol;β-Bromobenzeneethanol;β-Bromophenethyl alcohol;Benzeneethanol, b-bromo-
• CAS NO: 41252-83-9
• Molecular Formula: C₈H₉BrO
• Molecular Weight: 0
• Mol File: 41252-83-9.mol
• Article Data: 54

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Phenyl-2-bromoethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenyl-2-bromoethanol(41252-83-9)
• EPA Substance Registry System: 2-Phenyl-2-bromoethanol(41252-83-9)

Safety Data

• Hazardous Substances Data: 41252-83-9(Hazardous Substances Data)

Upstream product

• 96-09-3 styrene oxide 
• 4870-65-9 2-bromophenylacetic acid 
• 20780-53-4 (R)-Styrene oxide 
• 920-39-8 isopropylmagnesium bromide 
• 68-12-2 N,N-dimethyl-formamide 
• 529-64-6 Tropic acid 
• 93-56-1 phenylethane 1,2-diol 
• 100-42-5 styrene 
• 3277-26-7 1,1,3,3-Tetramethyldisiloxane 
• 106-95-6 allyl bromide 

Downstream Products

• 20245-72-1 2-phenyl-2-pyrrolidin-1-yl-ethanol 
• 91523-93-2 N-(2-Bromo-2-phenylethoxy)phthalimide 
• 91523-91-0 N-(2-Bromo-1-phenylethoxy)phthalimide 
• 91523-90-9 2,2'-((1-phenylethane-1,2-diyl)bis(oxy))bis(isoindoline-1,3-dione) 
• 27150-91-0 α-phenyl-β-propiolactone 
• 99884-77-2 phosphorodichloridic acid, 2-bromo-2-phenylethyl ester 
• 87767-94-0 2-bromo-2-phenylethyl acetate 
• 117416-47-4 Benzyl-carbamic acid 2-bromo-2-phenyl-ethyl ester 
• 175443-41-1 2-bromophenethyl N,N-bis(2-chloroethyl)chlorophosphoramidite 
• 175443-42-2 2-bromophenethyl N,N,N',N'-tetrakis(2-chloroethyl)chlorophosphoramidate 
• 111203-34-0 1-Tetrahydropyranyl-(2-brom-2-phenyl)ethylether 
• 245759-95-9 1-bromo-1-phenyl-2-(tert-butyldimethylsiloxy)ethane 
• 332868-65-2 2-bromo-2-phenylethyl (diphenylhydrazono)acetate 
• 4427-92-3 4-Phenyl-1,3-dioxolan-2-one 

Relevant articles and documents

Ni-Catalyzed Formal Cross-Electrophile Coupling of Alcohols with Aryl Halides

Direct coupling of unactivated alcohols remains a challenge in current synthetic chemistry. We herein demonstrate a strategy building upon in situ halogenation/reductive coupling of alcohols with aryl halides to forge Csp2-Csp3 bonds. The combination of 2-chloro-3-ethylbenzo[d]oxazol-3-ium salt (CEBO) and TBAB as the mild bromination reagents enables rapid transformation of a wide range of alcohols to their bromide counterparts within one to 5 min in CH3CN and DMF, which is compatible with the Ni-catalyzed cross-electrophile coupling conditions in the presence of a chemical reductant. The present method is suitable for arylation of a myriad of structurally complex alcohols with no need for prepreparation of alkyl halides. More importantly, the mild and kinetically rapid bromination process has shown good selectivity in the bromination/arylation of symmetric diols and less sterically hindered hydroxyl groups in polyols, thus offering promise for selective functionalization of diols and polyols without laborious protecting/deprotecting operations. The practicality of this work is also evident in the arylation of a number of carbohydrates, drug compounds, and naturally occurring alcohols.

Use of allylzinc halide as a source of halide: Differential addition of nucleophiles to Ts-aziridines and aldehydes under similar reaction conditions

We have observed that the allylic zinc halide under identical reaction conditions acts in different modes for different electrophiles. For Ts-aziridines the halide part of the allylic halide has been introduced as a nucleophile and for the carbonyl compou

LiBr/β-CD/IBX/H2O-DMSO: A new approach for one-pot biomimetic regioselective ring opening of chalcone epoxides to bromohydrins and conversion to 1,2,3-triketones

Highly regioselective ring cleavage of chalcone epoxides to bromohydrins has been carried out in good yields with LiBr in the presence of β-CD using DMSO-H2O as solvent system. The ring-opened product, i.e., bromohydrin, was well adapted to IBX-mediated oxidation in such a fashion that the bromohydrins are transformed to their corresponding 1,2,3-triketones in moderate-to-good yields in one pot.