41255-19-0

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 2-[1,1'-biphenyl]-4-yl-
• Synonyms: 4H-1-Benzopyran-4-one,2-[1,1'-biphenyl]-4-yl;2-([1,1'-biphenyl]-4-yl)-4H-chromen-4-one;2-biphenyl-4-yl-chromen-4-one;4'phenylflavone
• CAS NO: 41255-19-0
• Molecular Formula: C21H14O2
• Molecular Weight: 298.341
• Mol File: 41255-19-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 2-[1,1'-biphenyl]-4-yl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 2-[1,1'-biphenyl]-4-yl-(41255-19-0)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 2-[1,1'-biphenyl]-4-yl-(41255-19-0)

Safety Data

• Hazardous Substances Data: 41255-19-0(Hazardous Substances Data)

Upstream product

• 41255-15-6 (E)-3-([1,1′-biphenyl]-4-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one 
• 132351-68-9 3-(4-bromophenyl)-4H-1-benzopyran-4-one 
• 98-80-6 phenylboronic acid 
• 41255-15-6 2'-Hydroxy-4-phenylchalkon 
• 100954-86-7 4-phenylcinnamoyl chloride 
• 108-95-2 phenol 
• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 144432-80-4 2-(biphenyl-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1370422-33-5 4-(2,2-dichlorovinyl)-1,1'-biphenyl 
• 90-02-8 salicylaldehyde 
• 109899-87-8 1-(4'-bromophenyl)-3-(2-hydroxyphenyl)propane-1,3-dione 
• 36695-16-6 2-(4-bromobenzoyloxy)acetophenone 
• 65786-14-3 4-bromo-2'-hydroxylchalcone 
• 3218-36-8 4-Phenylbenzaldehyde 

Relevant articles and documents

A novel one-pot synthesis of flavones

In this paper, a one-pot facile route for the BiCl3/RuCl3-mediated synthesis of functionalized flavones is described, including: (i) intermolecularortho-acylation of substituted phenols with cinnamoyl chlorides, and (ii) intramolecular cyclodehydrogenation of the resultingo-hydroxychalcones. The reaction conditions are discussed herein.

A versatile approach to flavones via a one-pot Pd(II)-catalyzed dehydrogenation/oxidative boron-Heck coupling sequence of chromanones

A variety of flavones were expediently synthesized from readily accessible chromanones via a one-pot sequence involving Pd(ii)-catalyzed dehydrogenation and oxidative boron-Heck coupling with arylboronic acid pinacol esters. In particular, the use of arylboronic acid pinacol esters was found to significantly improve the yield of the reaction.

Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds

Malaria is responsible for nearly one million deaths annually, and the increasing prevalence of multi-resistant strains of Plasmodium falciparum poses a great challenge to controlling the disease. A diverse set of flavones, isosteric to 4(1H)-quinolones, were prepared and profiled for their antiplasmodial activity against the blood stage of P. falciparum W2 strain, and the liver stage of the rodent parasite Plasmodium berghei. Ligand efficient leads were identified as dual stage antimalarials, suggesting that scaffold optimization may afford potent antiplasmodial compounds.