412919-79-0Relevant articles and documents
The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone
Lin, Shu-Yu,Kuo, Yu-Hsien,Tien, Ya-Wen,Ke, Yi-Yu,Chang, Wan-Ting,Chang, Hsiao-Fu,Ou, Li-Chin,Law, Ping-Yee,Xi, Jing-Hua,Tao, Pao-Luh,Loh, Horace H.,Chao, Yu-Sheng,Shih, Chuan,Chen, Chiung-Tong,Yeh, Shiu-Hwa,Ueng, Shau-Hua
, p. 312 - 323 (2019/02/20)
Morphine is widely used for the treatment of severe pain. This analgesic effect is mediated principally by the activation of μ-opioid receptors (MOR). However, prolonged activation of MOR also results in tolerance, dependence, addiction, constipation, nau