41340-34-5

Basic information

• Product Name: 1H-INDOLE-3-ETHANOL,7-CHLORO-
• Synonyms: 1H-INDOLE-3-ETHANOL,7-CHLORO-;2-(7-Chloro-1H-indol-3-yl)ethanol
• CAS NO: 41340-34-5
• Molecular Formula: C10H10ClNO
• Molecular Weight: 195.65
• Mol File: 41340-34-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-INDOLE-3-ETHANOL,7-CHLORO-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDOLE-3-ETHANOL,7-CHLORO-(41340-34-5)
• EPA Substance Registry System: 1H-INDOLE-3-ETHANOL,7-CHLORO-(41340-34-5)

Safety Data

• Hazardous Substances Data: 41340-34-5(Hazardous Substances Data)

Usage

Derivative of

Indole

Characterized by

Chlorine atom at the 7th position

Potential pharmaceutical applications

Antipsychotic, sedative, antimicrobial, and anti-inflammatory properties

Importance in medicinal chemistry

Building block in drug development and therapeutic applications

Upstream product

• 863289-30-9 (7-Chloro-1H-indol-3-yl)-oxo-acetic acid ethyl ester 
• 53924-05-3 7-chloro-1H-indole 
• 863289-28-5 2-(7-chloro-1H-indol-3-yl)-2-oxoacetyl chloride 
• 526-55-6 2-(3-indole)-ethanol 
• 1191-99-7 2,3-dihydro-2H-furan 
• 41052-75-9 o-chlorophenylhydrazine hydrochloride 

Downstream Products

• 863289-25-2 3-(2-bromo-ethyl)-7-chloro-1H-indole 
• 870481-85-9 7-chloro-3-(2-iodo-ethyl)-1H-indole 

Relevant articles and documents

Au(I)-Catalyzed Domino Cyclization of 1,6-Diynes Incorporated with Indole

We disclose herein a Au(I)-catalyzed domino cyclization of 1,6-diynes incorporated with indole. This protocol enabled the diastereoselective buildup of indole-fused azabicyclo[3.3.1]nonanes from linear precursors. Density functional theory calculations showed that the reaction proceeded via an unprecedented cascade dearomatization/rearomatization/dearomatization process. Independent gradient model analysis revealed that a noncovalent attractive interaction between the distal alkyne and the Au/proximal complex was responsible for the chemoselectivity of the first spirocyclization step.

Structure-activity relationship study of novel necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-α. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). A SAR study revealed that several positions of the indole were intolerant of substitution, while small substituents at the 7-position resulted in increased inhibitory activity. The hydantoin ring was also quite sensitive to structural modifications. A representative member of this compound class demonstrated moderate pharmacokinetic characteristics and readily entered the central nervous system upon intravenous administration.

SUBSTITUTED INDOLE DERIVATIVES

Provided herein are indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.