413577-19-2Relevant articles and documents
A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: Design, synthesis, DNA binding, and anticancer properties
Kupchinsky, Stanley,Centioni, Sara,Howard, Tiffany,Trzupek, John,Roller, Shane,Carnahan, Virginia,Townes, Heather,Purnell, Bethany,Price, Carly,Handl, Heather,Summerville, Kaitlin,Johnson, Kimberly,Toth, James,Hudson, Stephen,Kiakos, Konstantinos,Hartley, John A.,Lee, Moses
, p. 6221 - 6236 (2007/10/03)
The synthesis, DNA binding properties, and in vitro and in vivo anticancer activity of fifteen achiral seco-cyclopropylindoline (or achiral seco-CI) analogs (5a-o) of CC-1065 and the duocarmycins are described. The achiral seco-CI analogs contain a 4-hydr
