413589-34-1

Basic information

• Product Name: 3-CHLORO-4-FLUOROPHENYLMAGNESIUM BROMID&
• Synonyms: 3-CHLORO-4-FLUOROPHENYLMAGNESIUM BROMID&;3-chloro-4-fluorophenylmagnesium bromide solution;3-Chloro-4-fluorophenylmagnesium bromide solution 0.5 in THF;3-Chloro-4-fluorophenylmagnesium bromide, 0.5M solution in THF, AcroSeal;3-Chloro-4-fluorophenylMagnesiuM broMide, 0.50 M in 2-MeTHF;broMo(3-chloro-4-fluorophenyl)MagnesiuM;3-Chloro-4-fluorophenylMagnesiuM broMide, 0.5 M solution in THF, SpcSeal;3-Chloro-4-fluorophenylmagnesium bromide solution 0.5 M in THF
• CAS NO: 413589-34-1
• Molecular Formula: C6H3BrClFMg
• Molecular Weight: 233.7484232
• Product Categories: Aryl;Grignard Reagents;Organometallic Reagents;Chemical Synthesis;Grignard Reagents;Organometallic Reagents;Grignard Reagent
• Mol File: 413589-34-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 65 °C
• Flash Point: 1 °F
• Appearance: /
• Density: 0.966 g/mL at 25 °C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-CHLORO-4-FLUOROPHENYLMAGNESIUM BROMID&(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-FLUOROPHENYLMAGNESIUM BROMID&(413589-34-1)
• EPA Substance Registry System: 3-CHLORO-4-FLUOROPHENYLMAGNESIUM BROMID&(413589-34-1)

Safety Data

• Hazard Codes: F,C
• Statements: 11-14-19-22-34-40-37
• Safety Statements: 16-26-36/37/39-45
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 1
• Hazardous Substances Data: 413589-34-1(Hazardous Substances Data)

Usage

General Description

The chemical 3-chloro-4-fluorophenylmagnesium bromide is an organometallic compound that contains a magnesium atom bonded to a phenyl group with a fluorine and chlorine substituent. It is commonly used as a reagent in organic synthesis, particularly in Grignard reactions, where it can act as a nucleophile to form carbon-carbon bonds. It is a versatile and widely used reagent in the preparation of various organic compounds, including pharmaceuticals, agrochemicals, and materials. It is typically prepared in situ from the reaction of 3-chloro-4-fluorobenzene with magnesium and bromine.

InChI:InChI=1/C6H3ClF.BrH.Mg/c7-5-3-1-2-4-6(5)8;;/h2-4H;1H;/q;;+1/p-1/rC6H3BrClFMg/c7-10-4-1-2-6(9)5(8)3-4/h1-3H

Upstream product

• 60811-21-4 1-bromo-3-chloro-4-fluorobenzene 

Downstream Products

• 1422186-93-3 C₂₅H₂₆ClF₂N₅O₂ 
• 1422186-92-2 C₂₅H₂₆ClF₂N₅O₂ 
• 1422186-91-1 C₂₅H₂₆ClF₂N₅O₂ 
• 1422186-90-0 C₂₅H₂₆ClF₂N₅O₂ 
• 1312718-88-9 2-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-fluorophenyl)ethanone 
• 1453847-89-6 (S)-1-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one 
• 1453849-07-4 1-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one 

Relevant articles and documents

PYRROLIDINE DERIVATIVE

The present invention aims to provide a novel compound which has CGRP receptor antagonist activity and which is useful for the treatment of various diseases mediated by CGRP receptors. That is, the present invention relates to the pyrrolidine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. In the formulae, W is ring, X is a carbon atom or the like, Y1 to Y4 are carbon atoms or the like, and R1 to R7 is alkyl or the like. The compounds of the present invention or a pharmaceutically acceptable salt thereof have an excellent CGRP receptor antagonist activity, and thus are useful as agents for the treatment of various diseases mediated by CGRP receptors.