413610-66-9

Basic information

• Product Name: N-(2-acetylphenyl)adamantane-1-carboxamide
• Synonyms: N-(2-acetylphenyl)adamantane-1-carboxamide
• CAS NO: 413610-66-9
• Molecular Weight: 297.397
• Mol File: 413610-66-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2-acetylphenyl)adamantane-1-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-acetylphenyl)adamantane-1-carboxamide(413610-66-9)
• EPA Substance Registry System: N-(2-acetylphenyl)adamantane-1-carboxamide(413610-66-9)

Safety Data

• Hazardous Substances Data: 413610-66-9(Hazardous Substances Data)

Upstream product

• 551-93-9 2-aminoacetophenone 
• 2094-72-6 1-Adamantanecarbonyl chloride 
• 2142-69-0 2-bromophenyl methyl ketone 
• 5511-18-2 adamantane-1-carboxamide 

Relevant articles and documents

Selective Oxidative Decarbonylative Cleavage of Unstrained C(sp3)-C(sp2) Bond: Synthesis of Substituted Benzoxazinones

A transition metal (TM)-free practical synthesis of biologically relevant benzoxazinones has been established via a selective oxidative decarbonylative cleavage of an unstrained C(sp3)-C(sp2) bond employing iodine, sodium bicarbonate, and tbutyl hydroperoxide in DMSO at 95 °C. Control experiments and Density Functional Theory (DFT) calculations suggest that the reaction involves a [1,5]H shift and extrusion of CO gas as the key steps. The extrusion of CO has also been established using PMA-PdCl2.

A mild, one-pot synthesis of 4-quinolones via sequential Pd-catalyzed amidation and base-promoted cyclization

(Chemical Equation Presented) A mild, one-pot synthesis of 4-quinolones is described. Under the optimal conditions, a variety of 2-substituted 4-quinolones were synthesized via sequential palladium-catalyzed amidation of 2′-bromoacetophenones followed by base-promoted intramolecular cyclization.