41381-33-3

Basic information

• Product Name: 1-IODO-2,3,4-TRIMETHYLBENZENE
• Synonyms: 1-IODO-2,3,4-TRIMETHYLBENZENE
• CAS NO: 41381-33-3
• Molecular Formula: C₉H₁₁I
• Molecular Weight: 246.09
• Mol File: 41381-33-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-IODO-2,3,4-TRIMETHYLBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-IODO-2,3,4-TRIMETHYLBENZENE(41381-33-3)
• EPA Substance Registry System: 1-IODO-2,3,4-TRIMETHYLBENZENE(41381-33-3)

Safety Data

• Hazardous Substances Data: 41381-33-3(Hazardous Substances Data)

Usage

Type of compound

Halogenated derivative of trimethylbenzene

Iodine attachment

First carbon of the benzene ring

Uses

Organic synthesis, intermediate in production of pharmaceuticals, agrochemicals, and specialty chemicals, reagent in synthesis of various organic compounds, precursor for production of iodinated organic compounds

Hazardous nature

Potentially hazardous chemical, requires proper safety precautions and regulations for handling and disposal.

Upstream product

• 1467-35-2 2,3,4-trimethylaniline 
• 526-73-8 1,2,3-trimethylbenzene 

Downstream Products

• 41571-49-7 4,5-Diiod-1,2,3-trimethylbenzol 
• 106994-05-2 2-(2,3,4-trimethylphenyl)pyridine 
• 86489-56-7 2-(2,3,4-Trimethyl-phenyl)-malononitrile 
• 805240-81-7 (2R,3S,5R)-2-Hydroxymethyl-5-(2,3,4-trimethyl-phenyl)-tetrahydro-furan-3-ol 
• 805240-90-8 (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,3,4-trimethyl-phenyl)-tetrahydro-furan-3-ol 

Relevant articles and documents

Selective and effective iodination of alkyl-substituted benzenes with elemental iodine activated by Selectfluor F-TEDA-BF4

Selective direct introduction of an iodine atom into alkyl-substituted benzene derivatives was effectively achieved by reaction of target molecules with elemental iodine in the presence of 1-chloromethyl-4-fluoro- 1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Selectfluor F-TEDA-BF4). The number of iodine atoms introduced could be modulated by the molar ratio between substrate, iodine and F-TEDA-BF4.

Acid-Mediated Reaction of Bis(pyridine)iodonium(I) Tetrafluoroborate with Aromatic Compounds. A Selective and General Iodination Method

Reaction of aromatic compounds with bis(pyridine)iodonium(I) tetrafluoroborate (IPy2BF4) in the presence of HBF4 or CF3SO3H in CH2Cl2 at room temperature furnishes monoiodo derivatives with excellent regioselectivity and yields.Use of either acid gives comparable results with activated aromatics, whereas CF3SO3H is much more effective in the iodination of deactivated aromatics.

Halogenation Using Quaternary Ammonium Polyhalides. XIV. Aromatic Bromination and Iodination of Arenes by Use of Benzyltrimethylammonium Polyhalides-Zinc Chloride System

The reaction of arenes with benzyltrimethylammonium tribromide or benzyltrimethylammonium dichloroiodate in acetic acid in the presence of ZnCl2 at room temperature or at 70 deg C gave brome- or iodo-substituted arenes in good yield, respectively.