4141-08-6

Basic information

• Product Name: 2-AMINO-N-METHYLBENZAMIDE
• Synonyms: BUTTPARK 34\02-07;2-AMINO-N-METHYLBENZAMIDE;Benzamide, 2-amino-N-methyl- (9CI);2-Amino-N-methylbenzamide 98%;Benzamide, 2-amino-N-methyl-;2-(Methylcarbamoyl)aniline;[2-[(MethylaMino)carbonyl]phenyl]aMine;Anthranilic Acid MethylaMide
• CAS NO: 4141-08-6
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Product Categories: AMINEPRIMARY;AMIDE;Drug Intermediates;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 4141-08-6.mol
• Article Data: 56

Chemical Properties

• Melting Point: 75 °C
• Boiling Point: 346.7 °C at 760 mmHg
• Flash Point: 163.5 °C
• Appearance: /
• Density: 1.137 g/cm³
• Vapor Pressure: 5.66E-05mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO, Methanol
• PKA: 14.73±0.46(Predicted)
• CAS DataBase Reference: 2-AMINO-N-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-METHYLBENZAMIDE(4141-08-6)
• EPA Substance Registry System: 2-AMINO-N-METHYLBENZAMIDE(4141-08-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 4141-08-6(Hazardous Substances Data)

Usage

Description

2-AMINO-N-METHYLBENZAMIDE, also known as Aminomethyl Benzamide, is an organic compound with the chemical formula C8H10N2O. It is a white solid and is commonly used as a plant safening agent in the agricultural industry. Its chemical structure allows it to interact with various plant hormones and chemicals, making it a valuable compound for enhancing crop protection and yield.

Uses

Used in Agriculture:
2-AMINO-N-METHYLBENZAMIDE is used as a plant safening agent for enhancing the tolerance of crops to various fertilizers, fungicides, insecticides, and herbicides. It helps in reducing the potential negative effects of these chemicals on plant growth and development, ensuring a higher yield and better quality of the produce.
Used in Fertilizers:
2-AMINO-N-METHYLBENZAMIDE is used as a safening agent in the fertilizer industry to improve the efficiency of nutrient uptake by plants. It helps in reducing the potential phytotoxic effects of certain fertilizer components, allowing for better nutrient utilization and overall plant health.
Used in Fungicides:
In the fungicide industry, 2-AMINO-N-METHYLBENZAMIDE is used as a safening agent to minimize the potential negative impact of fungicides on plant growth. It helps in maintaining the balance between effective disease control and plant health, ensuring a robust and healthy crop.
Used in Insecticides:
2-AMINO-N-METHYLBENZAMIDE is used as a safening agent in the insecticide industry to reduce the potential negative effects of insecticides on non-target plants. It helps in protecting beneficial plants while effectively controlling pests, leading to a more sustainable and environmentally friendly approach to pest management.
Used in Herbicides:
In the herbicide industry, 2-AMINO-N-METHYLBENZAMIDE is used as a safening agent to protect desirable plants from the harmful effects of herbicides. It helps in ensuring selective weed control, allowing farmers to maintain a healthy and productive crop while effectively managing weed populations.

InChI:InChI=1/C8H10N2O/c1-10-8(11)6-4-2-3-5-7(6)9/h2-5H,9H2,1H3,(H,10,11)

Upstream product

• 118-48-9 isatoic anhydride 
• 74-89-5 methylamine 
• 88070-48-8 N-methylbenzamide 
• 16285-32-8 2,3-dihydro-3-methyl-2-phenylquinazolin-4(1H)-one 
• 4454-32-4 1-benzyl-2-methyl-1,2-dihydro-indazol-3-one 
• 118-92-3 anthranilic acid 
• 552-16-9 ortho-nitrobenzoic acid 
• 606-27-9 methyl 2-nitrobenzoate 
• 3400-29-1 N-methyl-2-nitrobenzamide 
• 593-51-1 methylamine hydrochloride 
• 28144-70-9 anthranilic acid amide 
• 5344-90-1 2-Aminobenzyl alcohol 
• 610-14-0 2-nitrobenzyl chloride 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 59525-16-5 2-acetamido-N-methylbenzamide 
• 127082-54-6 2-Benzamido-N-methylbenzamide 
• 607-19-2 3-methyl-2,4(1H,3H)-quinazolinedione 
• 2436-66-0 3-methylquinazolin-4(3H)-one 
• 16353-13-2 N-formyl-anthranilic acid methylamide 
• 57946-97-1 N-methyl-2-(trifluoromethanesulfonamido)benzamide 
• 28257-01-4 2,3-dihydro-3-methyl-2-phenylbenzo[d][1,3,2]diazaborinin-4(1H)-one 
• 105189-33-1 3-Methyl-2-[3-(3-piperidin-1-ylmethyl-phenoxy)-propyl]-3H-quinazolin-4-one; compound with (Z)-but-2-enedioic acid 
• 76164-69-7 Ethyl 3-(2-N-Methylcarbamoylanilino)methylene-2,4-dioxovalerate 
• 142141-40-0 2-((ethylamino)methyl)aniline 
• 1904-69-4 2-amino-N-methylbenzylamine 
• 2415-10-3 2-amino-N-methylthiobenzamide 
• 53824-91-2 2-ω-chloroacetylamino-N-methylbenzamide 
• 74375-16-9 3-methyl-2-(4-methylphenyl)-4(3H)-quinazolinone 

Relevant articles and documents

Direct synthesis of quinazolinones via the carbon-supported acid-catalyzed cascade reaction of isatoic anhydrides with amides and aldehydes

A novel catalytic system is reported for the construction of quinazolinones via the carbon-supported acid-catalyzed cascade coupling of isatoic anhydrides with amides and aldehydes. Subsequent selective hydrosilylation of the quinazolinones using a hydrogen-transfer strategy was also explored to provide dihydroquinazolines with structural diversity. The developed methodology proceeds with a broad substrate scope, excellent functional group tolerance, and utilizes a reusable catalyst and air as a green oxidant.

Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate-Directed Formation of Quinolones versus Quinazolinones

Previous studies showed that the FeII/α-ketoglutarate dependent dioxygenase AsqJ induces a skeletal rearrangement in viridicatin biosynthesis in Aspergillus nidulans, generating a quinolone scaffold from benzo[1,4]diazepine-2,5-dione substrates. We report that AsqJ catalyzes an additional, entirely different reaction, simply by a change in substituent in the benzodiazepinedione substrate. This new mechanism is established by substrate screening, application of functional probes, and computational analysis. AsqJ excises H2CO from the heterocyclic ring structure of suitable benzo[1,4]diazepine-2,5-dione substrates to generate quinazolinones. This novel AsqJ catalysis pathway is governed by a single substituent within the complex substrate. This unique substrate-directed reactivity of AsqJ enables the targeted biocatalytic generation of either quinolones or quinazolinones, two alkaloid frameworks of exceptional biomedical relevance.

Palladium-catalyzed synthesis of novel trifluoromethylated quinazolinone, N-arylquinazoline and N-benzylquinazoline derivatives

A simple and palladium-catalyzed procedure for synthesis of a novel series of potentially biologically active trifluoromethyl-substituted quinazolinones and N-arylquinazoline derivatives via condensation-cyclization reaction of 2-aminobenzamide, 2-amino-N′-arylbenzimidamides and 2-amino-N′-benzylbenzimidamides with trifluoroacetimidoyl chlorides has been developed. noteworthy, this investigation showed the possible of transition-metal-catalyzed activation of trifluoroacetimidoyl chlorides as a carbon trifluoromethylated source for the synthesis of quinazolines and quinazolinone derivatives in good to excellent yields.