41410-43-9

Basic information

• Product Name: N''-cyano-N-(2-chlorophenyl)guanidine
• Synonyms: N''-cyano-N-(2-chlorophenyl)guanidine
• CAS NO: 41410-43-9
• Molecular Weight: 194.623
• Mol File: 41410-43-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N''-cyano-N-(2-chlorophenyl)guanidine(CAS DataBase Reference)
• NIST Chemistry Reference: N''-cyano-N-(2-chlorophenyl)guanidine(41410-43-9)
• EPA Substance Registry System: N''-cyano-N-(2-chlorophenyl)guanidine(41410-43-9)

Safety Data

• Hazardous Substances Data: 41410-43-9(Hazardous Substances Data)

Upstream product

• 1934-75-4 sodium dicyanamide 
• 95-51-2 o-chloroaniline 
• 120776-58-1 C₈H₄ClF₃N₂ 
• 142-04-1 aniline hydrochloride 

Downstream Products

• 861393-17-1 N-(1-{[[(2-chlorophenyl)amino](cyanoimino)methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide 

Relevant articles and documents

Discovery and biological evaluation of novel cyanoguanidine P2X7 antagonists with analgesic activity in a rat model of neuropathic pain

We disclose the design of a novel series of cyanoguanidines that are potent (IC50 ? 10-100 nM) and selective (≥100-fold) P2X7 receptor antagonists against the other P2 receptor subtypes such as the P2Y2, P2X4, and P2X3. We also found that these P2X7 antagonists effectively reduced nociception in a rat model of neuropathic pain (Chung model). Particularly, analogue 53 proved to be effective in the Chung model, with an ED50 of 38 μmol/kg after intraperitoneal administration. In addition compound 53 exhibited antiallodynic effects following oral administration and maintained its efficacy following repeated administration in the Chung model. These results suggest an important role of P2X7 receptors in neuropathic pain and therefore a potential use of P2X7 antagonists as novel therapeutic tools for the treatment of this type of pain.

The synthesis of 3,5-diamino-1,2,4-oxadiazoles. 2nd Communication

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