41444-33-1

Basic information

• Product Name: 1-(2-Thienylthio)acetone
• Synonyms: 1-(2-THIENYLTHIO)ACETONE;(2-THIENYLTHIO)ACETONE;(THIEN-2-YLTHIO)ACETONE;1-(2-Thienylsulfanyl)acetone;(2-THIENYLTHIO)ACETONE 98%;1-Thiophen-2-ylsulfanylpropan-2-one
• CAS NO: 41444-33-1
• Molecular Formula: C₇H₈OS₂
• Molecular Weight: 172.27
• Mol File: 41444-33-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 260.8°C at 760 mmHg
• Flash Point: 111.5°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 1-(2-Thienylthio)acetone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Thienylthio)acetone(41444-33-1)
• EPA Substance Registry System: 1-(2-Thienylthio)acetone(41444-33-1)

Safety Data

• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 41444-33-1(Hazardous Substances Data)

Usage

General Description

1-(2-Thienylthio)acetone, also known as tiopronin, is a chemical compound with the molecular formula C6H8OS2. It is a thiol-containing compound with a thione group that is commonly used as a pharmaceutical agent for the treatment of cystinuria and nephrolithiasis. Tiopronin has been shown to be a chelating agent, which means it can bind to heavy metals and help remove them from the body. In addition, it has been studied for its potential antioxidant and anti-inflammatory properties. Tiopronin is also used in the synthesis of various organic compounds and as a reagent in chemical reactions. Overall, 1-(2-Thienylthio)acetone has a wide range of applications in the medical, pharmaceutical, and chemical industries.

InChI:InChI=1/C7H8OS2/c1-6(8)5-10-7-3-2-4-9-7/h2-4H,5H2,1H3

Upstream product

• 188290-36-0 thiophene 
• 35928-65-5 (methylthio)acetyl chloride 
• 88-15-3 2-Acetylthiophene 
• 624-92-0 Dimethyldisulphide 
• 10531-41-6 2-Bromoacetylthiophene 
• 5188-07-8 sodium thiomethoxide 
• 2373-51-5 chloro-methylsulfanyl-methane 
• 229970-94-9 N‐methoxy‐N‐methyl‐2‐thiophenecarboxamide 

Downstream Products

• 1292821-94-3 C₂₄H₂₂N₂O₂S₂ 

Relevant articles and documents

Substituted α-Sulfur Methyl Carbanions: Effective Homologating Agents for the Chemoselective Preparation of β-Oxo Thioethers from Weinreb Amides

The proper generation of α-thiomethyllithium reagents via reductive lithiation or deprotonation followed by reaction with variously functionalized Weinreb amides represents an excellent method to access β-oxo thioethers. The procedure is adaptable to alky

SYNTHESIS AND CONFORMATIONAL ANALYSIS OF 2-METHYLTHIO DERIVATIVES OF 1-(2-THIENYL)ETHANOL AND THEIR O-METHYL DERIVATIVES

The synthesis and conformational analysis of the title compounds are reported.The conformational properties of the 2-thienyl derivatives, deduced from 1H-nmr and ir data, are compared with those for 2-furyl analogs and the results have been interpreted taking into account the stronger (OH...Ring) intramolecular association in the 2-furyl derivatives.