41456-51-3

Basic information

• Product Name: N,2,3-trimethylaniline
• Synonyms: N,2,3-trimethylaniline
• CAS NO: 41456-51-3
• Molecular Formula: C₉H₁₃N
• Molecular Weight: 135.21
• Mol File: 41456-51-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N,2,3-trimethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N,2,3-trimethylaniline(41456-51-3)
• EPA Substance Registry System: N,2,3-trimethylaniline(41456-51-3)

Safety Data

• Hazardous Substances Data: 41456-51-3(Hazardous Substances Data)

Upstream product

• 156267-24-2 Benzotriazol-1-ylmethyl-(2,3-dimethyl-phenyl)-amine 
• 160852-85-7 2-[2-(2-methoxyethoxy)ethoxy]ethyl methyl carbonate 
• 87-59-2 2,3-Dimethylaniline 
• 14719-31-4 N-(2,3-dimethylphenyl)-2,2,2-trifluoroacetamide 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 83-41-0 2,3-dimethylnitrobenzene 
• 95-47-6 o-xylene 
• 25370-97-2 O-(p-toluenesulfonyl)-N-methylhydroxylamine 
• 876353-79-6 N-tert-butyloxycarbonyl-2,3-dimethylaniline 

Downstream Products

• 876512-84-4 (2,3-dimethyl-phenyl)-methyl-carbamoyl chloride 
• 86626-96-2 (6-Chloro-2-methylsulfanyl-pyrimidin-4-yl)-(2,3-dimethyl-phenyl)-methyl-amine 
• 86627-09-0 2-p-Methoxybenzylthio-4-chloro-6-(N-methyl-2,3-xylidino)-pyrimidine 
• 86627-38-5 {4-Chloro-6-[(2,3-dimethyl-phenyl)-methyl-amino]-pyrimidin-2-ylsulfanyl}-acetic acid ethyl ester 
• 184870-83-5 N-Methyl-N-(2,3-dimethylphenyl)-2-bromoacetamide 
• 183180-25-8 N-Methyl-N-(2,3-dimethylphenyl)-2-[3-[N-(2-aminoacetyl)-N-(N-methyl-N-phenylcarbamoylmethyl)amino]phenoxy]acetamide 
• 183180-26-9 N-methyl-N-(2,3-dimethylphenyl)-2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]-N-(N-methyl-N-phenylcarbamoylmethyl)amino}phenoxy)acetamide 
• 1027418-66-1 1,4-Dimethyl-2-thioxo-2,3-dihydro-1H-indole-3-carboxylic acid phenylamide 
• 86627-48-7 4-Chloro-6-[(2,3-dimethyl-phenyl)-methyl-amino]-pyrimidine-2-thiol 
• 86627-51-2 6-Chloro-N⁴-(2,3-dimethyl-phenyl)-N²,N²,N⁴-trimethyl-pyrimidine-2,4-diamine 
• 86627-19-2 N-[4-chloro-6-(N-methyl-2,3-xylidino)-2-pyrimidinyl]-aminoacetic acid 
• 86627-32-9 [4-chloro-6-(N-methyl-2,3-xylidino)-2-pyrimidinyl]-oxyacetic acid 
• 86627-01-2 2-Methylsulfonyl-4-chloro-6-(N-methyl-2,3-xylidino)-pyrimidine 
• 86627-20-5 N-[4-chloro-6-(N-methyl-2,3-xylidino)-2-pyrimidinyl]-aminoacetic acid, ethyl ester 

Relevant articles and documents

Regioselective Radical Arene Amination for the Concise Synthesis ofortho-Phenylenediamines

The formation of arene C-N bonds directly from C-H bonds is of great importance and there has been rapid recent development of methods for achieving this through radical mechanisms, often involving reactiveN-centered radicals. A major challenge associated with these advances is that of regiocontrol, with mixtures of regioisomeric products obtained in most protocols, limiting broader utility. We have designed a system that utilizes attractive noncovalent interactions between an anionic substrate and an incoming radical cation in order to guide the latter to the areneorthoposition. The anionic substrate takes the form of a sulfamate-protected aniline and telescoped cleavage of the sulfamate group after amination leads directly toortho-phenylenediamines, key building blocks for a range of medicinally relevant diazoles. Our method can deliver both free amines and monoalkyl amines allowing access to unsymmetrical, selectively monoalkylated benzimidazoles and benzotriazoles. As well as providing concise access to valuableortho-phenylenediamines, this work demonstrates the potential for utilizing noncovalent interactions to control positional selectivity in radical reactions.

N-Methylation of amines and nitroarenes with methanol using heterogeneous platinum catalysts

We report herein the selective N-methylation of amines and nitroarenes with methanol under basic conditions using carbon-supported Pt nanoparticles (Pt/C) as a heterogeneous catalyst. This method is widely applicable to four types of N-methylation reactions: (1) N,N-dimethylation of aliphatic amines under N2, (2) N-monomethylation of aliphatic amines under 40 bar H2, (3) N-monomethylation of aromatic amines under N2, and (4) tandem synthesis of N-methyl anilines from nitroarenes and methanol under 2 bar H2. All these reactions under the same catalytic system showed high yields of the corresponding methylamines for a wide range of substrates, high turnover number (TON), and good catalyst reusability. Mechanistic studies suggested that the reaction proceeded via a borrowing hydrogen methodology. Kinetic results combined with density functional theory (DFT) calculations revealed that the high performance of Pt/C was ascribed to the moderate metal–hydrogen bond strength of Pt.

INDAZOLEPROPIONIC ACID AMIDE COMPOUND

Disclosed is a compound which is useful in preventing and treating cardiac arrhythmia such as atrial fibrillation. A compound represented by formula (1) or a pharmaceutically acceptable salt of the same. In formula (1), ring X represents benzene or pyridine; R1 represents an optionally substituted alkyl group; R2 represents an optionally substituted aryl group, an optionally substituted heterocyclic group, an optionally substituted arylalkyl group or an optionally substituted heterocyclic group-substituted alkyl group; R3, R4, R5, R6, R7, R8 and R9 represent each hydrogen or an alkyl group, provided that R3 and R5 may be bonded to each other to form, together with the carbon atom adjacent thereto, a cycloalkyl group; and m represents 0 or 1.