41555-47-9Relevant articles and documents
Acid-Mediated Three Component Assembly of 4-Fluoropyrazoles from α-Fluoronitroalkenes, Hydrazines, and Aldehydes
Ioffe, Sema L.,Motornov, Vladimir A.,Nelyubina, Yulia V.,Nenajdenko, Valentine G.,Tabolin, Andrey A.
, (2020/08/06)
A new approach for the synthesis of highly pharmaceutically relevant 4-fluoropyrazoles via oxidative annulation of α-fluoronitroalkenes with in situ prepared hydrazones was developed. The reaction is efficiently promoted by trifluoroacetic acid while atmo
Synthesis of 3-(2-nitrovinyl)-4H-chromones: Useful scaffolds for the construction of biologically relevant 3-(pyrazol-5-yl)chromones
Soengas, Raquel G.,Silva, Vera L.M.,Ide, Daisuke,Kato, Atsushi,Cardoso, Susana M.,Almeida Paz, Filipe A.,Silva, Artur M.S.
, p. 3198 - 3203 (2016/05/24)
The Henry-type Barbier addition of bromonitromethane to 3-formylchromone, immediately followed by acetylation and concomitant elimination to afford nitroalkenes in excellent yield and total (E)-selectivity is described. Cycloaddition of N-methylhydrazones
Regioselective synthesis of 4-nitro- or 4-chloro-tetrasubstituted pyrazoles from hydrazones and β-halo-β-nitrostyrenes
Deng, Xiaohu,Liang, Jimmy T.,Mani, Neelakandha S.
, p. 410 - 417 (2014/01/23)
We report an acid-catalyzed cycloaddition reaction of hydrazones with β-bromo- or β-chloro-β-nitrostyrenes for the regioselective synthesis of 4-nitro- or 4-chloro-tetrasubstituted pyrazoles. Arising from a common 4-halo-4-nitropyrazolidine intermediate,