41571-21-5

Basic information

• Product Name: 4-Morpholinamine, N-(phenylmethylene)-
• CAS NO: 41571-21-5
• Molecular Formula: C11H14N2O
• Molecular Weight: 190.245
• Mol File: 41571-21-5.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 4-Morpholinamine, N-(phenylmethylene)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Morpholinamine, N-(phenylmethylene)-(41571-21-5)
• EPA Substance Registry System: 4-Morpholinamine, N-(phenylmethylene)-(41571-21-5)

Safety Data

• Hazardous Substances Data: 41571-21-5(Hazardous Substances Data)

Upstream product

• 351186-41-9 4-methyl-N-morpholin-4-ylbenzenesulfonamide 
• 100-39-0 benzyl bromide 
• 119645-09-9 N-[(1,1-dimethylethyl)diphenylsilyl]benzenemethanamine 
• 110-91-8 morpholine 
• 1413917-20-0 N-[(1,1-dimethylethyl)diphenylsilyl]-3-phenyloxaziridine 
• 4319-49-7 1-aminomorpholine 
• 100-52-7 benzaldehyde 

Downstream Products

• 1619244-10-8 N-benzylmorpholin-4-amine oxalate 
• 1619244-20-0 N,N-dibenzylmorpholin-4-amine 

Relevant articles and documents

Cu-Catalyzed C(sp2?H)-Trifluoromethylation of Aldehyde Hydrazones with Langlois Reagent

The C(sp2?H)-trifluoromethylation of hydrazones would give access to the α-trifluoromethylated hydrazones that can serve as intermediates in the synthesis of pharmaceutically interesting fluorinated compounds. Herein, we demonstrate the Cu-cata

Structure–activity relationships (SARs) of α- ketothioamides as inhibitors of phosphoglycerate dehydrogenase (PHGDH)

For many years now, targeting deregulation within cancer cells’ metabolism has appeared as a promising strategy for the development of more specific and efficient cancer treatments. Recently, numerous reports highlighted the crucial role of the serine synthetic pathway, and particularly of the phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the pathway, to sustain cancer progression. Yet, because of very weak potencies usually in cell-based settings, the inhibitors reported so far failed to lay ground on the potential of this approach. In this paper, we report a structure–activity relationship study of a series of α-ketothioamides that we have recently identified. Interestingly, this study led to a deeper understanding of the structure–activity relationship (SAR) in this series and to the identification of new PHGDH inhibitors. The activity of the more potent compounds was confirmed by cellular thermal shift assays and in cell-based experiments. We hope that this research will eventually provide a new entry point, based on this promising chemical scaffold, for the development of therapeutic agents targeting PHGDH.

Visible-light-enabled C(sp2)-H difluoroalkylation of aldehyde-derived hydrazones under metal-free conditions

A Eosin Y-catalyzed C(sp2)-H difluoromethylation of aldehyde-derived hydrazones between difluoroalkyl bromides and aldehyde-derived hydrazones is reported. This reaction has a wide range of substrates and occurs under metal-free condition. A me