41598-07-6 Usage
Description
Prostaglandin D2 (PGD2) is a member of the prostaglandins D class, a fatty acid compound found in the human body. It is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 plays a role in various physiological processes, including vasodilation, flushing, hypotension, and syncopal episodes in mastocytosis patients. Additionally, it is involved in the regulation of sleep and body temperature in the brain, as well as the inhibition of platelet aggregation and relaxation of vascular smooth muscle.
Uses
Used in Pharmaceutical Applications:
PROSTAGLANDIN D2 is used as a therapeutic agent for the treatment of allergic asthma and anaphylaxis due to its role in the release from mast cells during these conditions.
Used in Sleep Regulation:
PROSTAGLANDIN D2 is used as a regulator of normal physiological sleep and body temperature in the brain, contributing to the maintenance of sleep-wake cycles and thermoregulation.
Used in Cardiovascular Applications:
PROSTAGLANDIN D2 is used as a vasodilator and inhibitor of platelet aggregation, which can help in the prevention of blood clot formation and the management of certain cardiovascular conditions.
Used in Oncology Research:
PROSTAGLANDIN D2 is used as an inhibitor of human ovarian tumor cell proliferation, with an IC50 of 6.8 μM, potentially contributing to the development of novel cancer treatments.
Used in Hair Growth Inhibition:
PROSTAGLANDIN D2 is used as a factor in hair loss and growth inhibition, as elevated levels of localized PGD2 have been linked to these conditions. This application could be relevant in the development of treatments for hair loss or as a tool in hair growth research.
Used in Allergy Research:
PROSTAGLANDIN D2 is used as a contributor to the activity of allergic asthma, making it a potential target for the development of new treatments or therapies for allergic reactions and asthma.
Biochem/physiol Actions
Primary prostaglandin in brain; induces inflammation; stimulates adenylyl cyclase.
Check Digit Verification of cas no
The CAS Registry Mumber 41598-07-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,5,9 and 8 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 41598-07:
(7*4)+(6*1)+(5*5)+(4*9)+(3*8)+(2*0)+(1*7)=126
126 % 10 = 6
So 41598-07-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1
41598-07-6Relevant articles and documents
Studies on the Properties of Prostaglandin Synthetase of Caprine Seminal Vesicles
Das, Mallika,Ghosh, Dolly
, p. 319 - 322 (2007/10/03)
The prostaglandin (PG) synthetase complex in the microsomal fraction of caprine (goat) seminal vesicles was found to have the highest PGE2 synthetase activity in comparison to that in similar other animal sources. The results of the investigations on the kinetics of PGE2 synthesis, factors influencing product formation, cofactor requirement and stability of the enzyme system show that the PG-synthetase complex from goat vesicular gland was very unstable, and its properties were generally comparable to that from the highly active ovine seminal vesicular multienzyme complex.
A novel synthesis of (±)-prostaglandin D2
Collington,Wallis,Waterhouse
, p. 3125 - 3128 (2007/10/02)
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