41602-56-6Relevant articles and documents
Turn on ESPT: Novel salicylaldehyde based sensor for biological important fluoride sensing
Liu, Kai,Zhao, Xiaojun,Liu, Qingxiang,Huo, Jianzhong,Fu, Huifang,Wang, Ying
, p. 75 - 79 (2014)
A novel and simple salicylaldehyde based anion fluorescent sensor 1 has been designed, which can selectively sense fluoride by 'turn on' excited-state intermolecular proton transfer (ESPT). The binding constant and the stoichiometry were obtained by non-linear least-square analysis of the titration curves.
Anagostic interactions in chiral separation. Polymorphism in a [Co(II)(L)] complex: Crystallographic and theoretical studies
Awwadi, Firas F.,Hodali, Hamdallah A.
, p. 373 - 381 (2018)
Syntheses and crystal structures of two polymorphs of the complex [Co(II)(L)], where H2L = 2,2’-[cis-1,2-diaminocyclohexanediylbis (nitrilo-methylidyne)]bis (5-dimethyl-amino]phenol, have been studied. The two polymorphs concomitantly crystallized by vapour diffusion of solvent. The first polymorph (I) crystallized as a racemate in the centrosymmetric tetragonal I41/a space group. The second polymorph (II) crystallized in the chiral orthorhombic space group P212121. The chiral conformers of symmetrical cis-1,2-disubstituted cyclohexane molecules cannot be resolved in the liquid or gas phases, due to the rapid ring inversion. In the present study, the two chiral conformers are present in crystals of polymorph I, whereas, only one chiral conformer is present in crystals of polymorph II. Crystal structure analysis indicated that the formation of two different polymorphs of [Co(II)(L)] complex can be rationalized based on C–H?Co anagostic interactions. Density Functional Theory (DFT) calculations indicated that C–H?Co interactions are due to HOMO-LUMO interactions.
Imidazolyl–benzocoumarins as ratiometric fluorescence probes for biologically extreme acidity
Kim, Hyerim,Sarkar, Sourav,Nandy, Madhurima,Ahn, Kyo Han
, (2021)
A rational approach to develop a fluorescent probe for sensing biologically “extreme” acidity (pH a = 1.3 among ratiometric probes known so far, which is ascribed due to a unique sensing mechanism. The probe has high quantum yields, high chemical stability and good aqueous solubility. The probe was successfully applied to ratiometric fluorescence imaging of intrabacterial acidity from pH 4.0–1.0, offering a practical means for studying biological systems under the extreme pH conditions.
Fluoride-driven 'turn on' ESPT in the binding with a novel benzimidazole-based sensor
Liu, Kai,Zhao, Xiaojun,Liu, Qingxiang,Huo, Jianzhong,Zhu, Bolin,Diao, Shihua
, p. 563 - 567 (2015)
A novel fluorescence sensor (BIP) bearing NH and OH subunits displayed a highly selective and sensitive recognition property for fluoride over other anions. Fluoride-driven ESPT, poorly used in anion recognition and sensing, was suggested to be responsible for the fluorescence enhancement with a blue shift of 35 nm in the emission spectrum.
ACYL SULFONAMIDES FOR TREATING CANCER
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Page/Page column 305, (2020/11/03)
The present invention provides acyl sulfonamide compounds of general formula (I): in which X, R1, R2, R3, R4, R5, R6, Ra and Rb are as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients as well as methods of treating and/or prophylaxing diseases, particularly cancer, more particularly cancer in which KAT6A and/or KAT6B is focally amplified, said method comprising administering an effective amount of at least one compound of formula (I) to a subject in need thereof.
