41637-07-4

Basic information

• Product Name: dichloroplatinum(2+) 3-carboxypiperidin-1-ide 5-carboxy-2H-pyridin-1-ide (1:1:1)
• CAS NO: 41637-07-4
• Molecular Formula: C₁₂H₁₆Cl₂N₂O₄Pt
• Molecular Weight: 518.2564
• Mol File: 41637-07-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 265.8°C at 760 mmHg
• Flash Point: 114.5°C
• Vapor Pressure: 0.0026mmHg at 25°C
• CAS DataBase Reference: dichloroplatinum(2+) 3-carboxypiperidin-1-ide 5-carboxy-2H-pyridin-1-ide (1:1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: dichloroplatinum(2+) 3-carboxypiperidin-1-ide 5-carboxy-2H-pyridin-1-ide (1:1:1)(41637-07-4)
• EPA Substance Registry System: dichloroplatinum(2+) 3-carboxypiperidin-1-ide 5-carboxy-2H-pyridin-1-ide (1:1:1)(41637-07-4)

Safety Data

• Hazardous Substances Data: 41637-07-4(Hazardous Substances Data)

Upstream product

• 59-67-6 nicotinic acid 
• 10025-99-7 potassium tetrachloroplatinate(II) 

Relevant articles and documents

The synthesis, structure-toxicity relationship of cisplatin derivatives for the mechanism research of cisplatin-induced nephrotoxicity

Cisplatin is a widely used antineoplastic drug, while its nephrotoxicity limits the clinical application. Although several mechanisms contributing to nephrotoxicity have been reported, the direct protein targets are unclear. Herein we reported the synthesis of 29 cisplatin derivatives and the structure-toxicity relationship (STR) of these compounds with MTT assay in human renal proximal tubule cells (HK-2) and pig kidney epithelial cells (LLC-PK1). To the best of our knowledge, this study represented the first report regarding the structure-toxicity relationship (STR) of cisplatin derivatives. The potency of biotin-pyridine conjugated derivative 3 met the requirement for target identification, and the preliminary chemical proteomics results suggested that it is a promising tool for further target identification of cisplatin-induced nephrotoxicity.