4167-75-3Relevant articles and documents
Non-catalytic anti-Markovnikov phenol alkylation with supercritical water
Sato, Takafumi,Ishiyama, Yasuyoshi,Itoh, Naotsugu
, p. 716 - 717 (2006)
The anti-Markovnikov alkylation of phenol with tert-butyl alcohol could be achieved without catalyst in supercritical water at 673 K. The dehydration of tert-butyl alcohol gave isobutene and was followed by the reaction with phenol to form 2-isobutylphenol as an anti-Markovnikov product, 2-tert-butylphenol and 4-tert-butylphenol. The hydroxy group probably participated in the anti-Markovnikov alkylation and the increase in water density enhanced the formation of 2-isobutylphenol as well as 4-tert-butylphenol. Copyright
Thermal Stability Study of 4-tert-Butylphenol
Shakun,Nesterova,Naumkin
, p. 120 - 127 (2019/04/27)
Abstract: The thermal stability of 4-tert-butylphenol has been studied in the temperature range of 673–738?K, the components of the thermolysis reaction mixture have been identified, a kinetic model of the process has been proposed, and the rate constants and parameters of the Arrhenius equation have been calculated for all of the reactions considered. The predominant role of 4-tert-butylphenol isomerization transformations has been established. Information on the 4-tert-butylphenol thermal stability facilitates to a more substantiated approach to its use as an additive that increases the oxidative stability of fuels and lubricants, as well as an antioxidant for polymer compositions.
A modular synthesis of teraryl-based α-helix mimetics, part 1: Synthesis of core fragments with two electronically differentiated leaving groups
Peters, Martin,Trobe, Melanie,Tan, Hao,Kleineweischede, Rolf,Breinbauer, Rolf
supporting information, p. 2442 - 2449 (2013/04/24)
Teraryl-based α-helix mimetics have proven to be useful compounds for the inhibition of protein-protein interactions (PPI). We have developed a modular and flexible approach for the synthesis of teraryl-based α-helix mimetics. Central to our strategy is the use of a benzene core unit featuring two leaving groups of differentiated reactivity in the Pd-catalyzed cross-coupling used for terphenyl assembly. With the halogen/diazonium route and the halogen/triflate route, two strategies have successfully been established. The synthesis of core building blocks with aliphatic (Ala, Val, Leu, Ile), aromatic (Phe), polar (Cys, Lys), hydrophilic (Ser, Gln), and acidic (Glu) amino acid side chains are reported. Turn on: Teraryl-based α-helix mimetics can be effectively produced by sequential Suzuki coupling of a central core fragment featuring electronically differentiated leaving groups with aryl boronic pinacol esters (see scheme; dppf=1,1′-bis(diphenylphosphino) ferrocene, DME=dimethoxyethane, Pin=pinacol, Tf=trifluoromethanesulfonyl). With a set of only 2×18 building blocks, all permutations of α-helix mimetics can be produced. Copyright
