41679-15-6

Basic information

• Product Name: (S)-2-aMino-3-(4-hydroxy-3-(hydroxyMethyl)phenyl)propanoic acid
• Synonyms: (S)-2-aMino-3-(4-hydroxy-3-(hydroxyMethyl)phenyl)propanoic acid;L-4-Hydroxy-3-hydroxymethylphenylalanine
• CAS NO: 41679-15-6
• Molecular Formula: C₁₀H₁₃NO₄
• Molecular Weight: 211.21452
• Mol File: 41679-15-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: >300℃
• Appearance: /
• Density: 1.411
• CAS DataBase Reference: (S)-2-aMino-3-(4-hydroxy-3-(hydroxyMethyl)phenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-aMino-3-(4-hydroxy-3-(hydroxyMethyl)phenyl)propanoic acid(41679-15-6)
• EPA Substance Registry System: (S)-2-aMino-3-(4-hydroxy-3-(hydroxyMethyl)phenyl)propanoic acid(41679-15-6)

Safety Data

• Hazardous Substances Data: 41679-15-6(Hazardous Substances Data)

Usage

Description

(S)-2-amino-3-(4-hydroxy-3-(hydroxymethyl)phenyl)propanoic acid, commonly known as dopa, is a vital non-essential amino acid that serves as a precursor in the biosynthesis of neurotransmitters such as dopamine, epinephrine, and norepinephrine. Derived from the amino acid phenylalanine, dopa is integral to various physiological processes and holds potential therapeutic applications.

Uses

Used in Pharmaceutical Industry:
Dopa is utilized as an active pharmaceutical ingredient for the treatment of Parkinson's disease. It functions as a precursor to dopamine, a neurotransmitter that is often deficient in patients with this condition. By replenishing dopamine levels, dopa can help alleviate symptoms and improve the quality of life for those affected.
Used in Neurodegenerative Disorder Treatment:
Dopa is being investigated for its potential neuroprotective and antioxidant properties, which may contribute to the treatment of other neurodegenerative disorders beyond Parkinson's disease. Its ability to combat oxidative stress and protect neurons could offer new therapeutic avenues for conditions like Alzheimer's and Huntington's disease.
Used in Cosmetics Industry:
In the cosmetics industry, dopa is used in the production of melanin, the pigment responsible for the color of skin, hair, and eyes. Its role in melanogenesis makes it a valuable compound for developing products that address pigmentation concerns and promote even skin tone.
Used in Research and Development:
Dopa's involvement in neurotransmitter synthesis and its potential therapeutic applications make it an important compound for research and development in the fields of neuroscience, pharmacology, and biotechnology. Further study of dopa may lead to the discovery of novel treatments for various neurological and psychiatric conditions.

Upstream product

• 90-01-7 salicylic alcohol 
• 127-17-3 2-oxo-propionic acid 
• 52186-44-4 (S)-N-benzyloxycarbonyl-4-hydroxy-3-hydroxymethylphenylalanine 
• 698386-61-7 benzyl (S)-4-(4H-1,3-benzodioxin-6-ylmethyl)-5-oxo-1,3-oxazolane-3-carboxylate 
• 1164-16-5 Z-L-Tyr-OH 
• 698386-62-8 (S)-2-(Benzyloxycarbonyl-hydroxymethyl-amino)-3-(4-hydroxy-3-hydroxymethyl-phenyl)-propionic acid 
• 35149-75-8 L-3-formyltyrosine hydrochloride 

Relevant articles and documents

A convenient two step transformation of tyrosine into the antihypertensive amino acid (S)-4-hydroxy-3-hydroxymethylphenylalanine

Treatment of tyrosine with paraformaldehyde and catalytic amounts of p-toluenesulfonic acid, at reflux in toluene, directly generates benzyl (S)-4-(4H-1,3-benzodioxin-6-ylmethyl)-5-oxo-1,3-oxazolane-3-carboxylate, which on treatment with boron trichloride in dichloromethane, affords (S)-4-hydroxy-3-hydroxymethylphenylalanine.

L-3-hydroxymethyltyrosine and salts thereof for lowering blood pressure

L-3-Hydroxymethyltyrosine and pharmaceutically acceptable salts thereof useful in lowering blood pressure and compositions thereof.