41680-92-6

Basic information

• Product Name: Benzoic acid, 4-amino-3-nitro-, butyl ester
• CAS NO: 41680-92-6
• Molecular Formula: C11H14N2O4
• Molecular Weight: 238.243
• Mol File: 41680-92-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-amino-3-nitro-, butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-amino-3-nitro-, butyl ester(41680-92-6)
• EPA Substance Registry System: Benzoic acid, 4-amino-3-nitro-, butyl ester(41680-92-6)

Safety Data

• Hazardous Substances Data: 41680-92-6(Hazardous Substances Data)

Upstream product

• 1588-83-6 4-amino-3-nitrobenzoic acid 
• 71-36-3 butan-1-ol 

Downstream Products

• 63655-47-0 n-Butyl 3,4-diaminobenzoate 

Relevant articles and documents

Studies in Antiparasitic Agents: Part 9 - Synthesis of 5(6)-Alkoxycarbonyl-2-substituted-benzimidazoles as Potential Anthelmintics

Methyl 5(6)-alkoxycarbonylbenzimidazole-2-carbamates (5a-5f) and 5(6)-carboxyl analogue (5g) and its salts (6a-6b) have been synthesized starting from 4-amino-3-nitrobenzoic acid (2), and their structures established by elemental analysis and spectral data.The drugs 5a-5g and 6a-6b have been tested for their anthelmintic activity in rodents infested by Ancylostoma ceylanicum, Syphacia obvelata, Nippostrongylus brasiliensis, Hymenolepis nana, Cysticercus fasciolaris, Litomosoides carinii and Dipetalonema viteae and found to cause 100percent elimination of A. ceylanicum hookworms at an oral dose of 25-250 mg/kg but not so effective against other helminths.

Process for the production of 2-aryl-2H-benzotriazoles

A process for the production of 2-aryl-2H-benzotriazoles comprises reducing and cyclizing the corresponding o-nitroazobenzenes with hydrogen at a temperature in the range of about 20° C. to about 100° C. and at a pressure in the range of about 15 psia (1 atmosphere) to about 1000 psia (66 atmospheres) in an organic solvent mixture containing an organic amine at a pH over 10 in the presence of noble metal hydrogenation catalyst, preferably palladium. High yields of pure product are obtained with a concomitant reduction of undesired by-products and a reduction in effluent pollution problems.

Process for the production of 2-aryl-2H-benzotriazoles

An improved process for the production of 2-aryl-2H-benzotriazoles by the reduction of o-nitroazobenzene intermediates with zinc in alkaline medium comprises employing a ratio of moles of alkali to moles of o-nitroazobenzene intermediate in the range of 0.2-1.7/1 in the presence of less than 150 ppm of iron based on zinc used. The improved process results in higher yields of high purity products with a concomitant reduction in the amount of undesired cleavage amine by-products and a reduction in effluent pollution problems. The process is carried out in a polar/non-polar solvent mixture.