41697-08-9

Basic information

• Product Name: 2-HYDROXY-4-METHOXYBENZENECARBOHYDRAZIDE
• Synonyms: ASISCHEM Z67645;2-HYDROXY-4-METHOXYBENZENECARBOHYDRAZIDE;2-HYDROXY-4-METHOXYBENZOHYDRAZIDE;2-HYDROXY-4-METHOXYBENZOIC ACID HYDRAZIDE;2-Hydroxy-4-methoxybenzohydrazide, 2-(Hydrazinocarbonyl)-5-methoxyphenol, 4-(Hydrazinocarbonyl)-3-hydroxyanisole
• CAS NO: 41697-08-9
• Molecular Formula: C₈H₁₀N₂O₃
• Molecular Weight: 182.18
• Product Categories: Carbonyl Compounds;Hydrazides;Organic Building Blocks
• Mol File: 41697-08-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 172-176 °C(lit.)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.307g/cm³
• Refractive Index: 1.594
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2-HYDROXY-4-METHOXYBENZENECARBOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-4-METHOXYBENZENECARBOHYDRAZIDE(41697-08-9)
• EPA Substance Registry System: 2-HYDROXY-4-METHOXYBENZENECARBOHYDRAZIDE(41697-08-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 41697-08-9(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-4-methoxybenzenecarbohydrazide is a chemical compound that falls under the category of organic compounds. Organic compounds are widely used in the scientific world for different purposes and the properties vary significantly from one to another. This particular compound is known for its benzenecarbohydrazidederivative properties. This complex combination of elements makes it ideal for various chemical reactions that can lead to the production of different compounds. The accurate information about its usage and effect on the human body or environment is limited, as different conditions and reactions could potentially change the nature or characteristics of the compound. Therefore, casual handling or use of this compound is not typically recommended due to the potential risks.

InChI:InChI=1/C8H10N2O3/c1-13-5-2-3-6(7(11)4-5)8(12)10-9/h2-4,11H,9H2,1H3,(H,10,12)

Upstream product

• 35031-00-6 ethyl 2-hydroxy-4-methoxybenzoate 
• 2237-36-7 4-methoxysalicylic acid 
• 5446-02-6 4-methoxymethylsalicylate 

Downstream Products

• 19949-26-9 2-(5-amino-[1,3,4]oxadiazol-2-yl)-5-methoxy-phenol 
• 19938-37-5 2-acetoxy-1-(5-acetylamino-[1,3,4]oxadiazol-2-yl)-4-methoxy-benzene 
• 19938-38-6 1-(5-benzoylamino-[1,3,4]oxadiazol-2-yl)-2-benzoyloxy-4-methoxy-benzene 
• 1257843-08-5 2-(5-mercapto-1,3,4-oxadiazol-2-yl)-5-methoxyphenol 
• 1357083-13-6 2-(5-(benzylthio)-1,3,4-oxadiazol-2-yl)-5-methoxyphenol 
• 1378258-45-7 5-methoxy-2-(5-((4-methoxybenzyl)thio)-1,3,4-oxadiazol-2-yl)phenol 
• 1378258-47-9 5-methoxy-2-(5-((2-nitrobenzyl)thio)-1,3,4-oxadiazol-2-yl)phenol 
• 1378258-48-0 5-methoxy-2-(5-((3-nitrobenzyl)thio)-1,3,4-oxadiazol-2-yl)phenol 
• 1378258-52-6 5-methoxy-2-(5-((4-nitrobenzyl)thio)-1,3,4-oxadiazol-2-yl)phenol 
• 1378258-31-1 2-(5-((2-chlorobenzyl)thio)-1,3,4-oxadiazol-2-yl)-5-methoxyphenol 
• 1378258-32-2 2-(5-((3-chlorobenzyl)thio)-1,3,4-oxadiazol-2-yl)-5-methoxyphenol 
• 1378258-34-4 2-(5-((4-chlorobenzyl)thio)-1,3,4-oxadiazol-2-yl)-5-methoxyphenol 
• 1378258-36-6 2-(5-((2-fluorobenzyl)thio)-1,3,4-oxadiazol-2-yl)-5-methoxyphenol 
• 1378258-37-7 2-(5-((4-fluorobenzyl)thio)-1,3,4-oxadiazol-2-yl)-5-methoxyphenol 

Relevant articles and documents

Design, synthesis, in vitro and in silico studies of novel Schiff base derivatives of 2-hydroxy-4-methoxybenzamide as tyrosinase inhibitors

Due to the fact that tyrosinase is responsible for biosynthesis and regulation of melanins and browning food products, tyrosinase inhibitors can be favorable agents in cosmetics and medicinal industries. A series of novel 2-hydroxy-4-methoxybenzohydrazide were designed, synthesized, and their new application as tyrosinase inhibitors was also disclosed. Based on in vitro tyrosinase inhibitory assay, 4d as the strongest inhibitor of tyrosinase with an IC50 value of 7.57 μM showed approximately 2.5-fold better inhibition than kojic acid as positive control followed by two compounds 4b (IC50?= 8.19 ± 0.25 μM) and 4j (IC50?= 8.92 ± 0.016) which displayed preferable tyrosinase inhibitory activity. Detailed investigations on the mechanism of action of the 4d reported mix type of inhibition. More importantly, molecular modeling assessments proposed the ability of 4d for potential interaction with Cu (metal)-His (residue) within tyrosinase active site. Overall, 4d is a promising candidate for the development of anti-tyrosinase agents.

Gold (I) phosphine complex containing 5-phenyl-1, 3, 4-oxadiazole-2-thione and preparation method and application of gold (I) phosphine complex

The invention discloses a gold (I) phosphine complex containing 5-phenyl-1, 3, 4-oxadiazole-2-thione and a preparation method and application of the gold (I) phosphine complex, and belongs to the technical field of inorganic medicinal chemistry. The struc

Synthesis, biological evaluation and molecular docking studies of novel 2-(1,3,4-oxadiazol-2-ylthio)-1-phenylethanone derivatives

In present study, a series of new 2-(1,3,4-oxadiazol-2-ylthio)-1- phenylethanone derivatives (6a-6x) as potential focal adhesion kinase (FAK) inhibitors were synthesized. The bioassay assays demonstrated that compound 6i showed the most potent activity, which inhibited the growth of MCF-7 and A431 cell lines with IC50 values of 140 ± 10 nM and 10 ± 1 nM, respectively. Compound 6i also exhibited significant FAK inhibitory activity (IC50 = 20 ± 1 nM). Docking simulation was performed to position compound 6i into the active site of FAK to determine the probable binding model.