4170-24-5

Basic information

• Product Name: 2-Chlorobutyric acid
• Synonyms: 2-CHLORO-N-BUTYRIC ACID;2-CHLOROBUTYRIC ACID;3-CHLORO-N-BUTYRIC ACID;3-CHLOROBUTYRIC ACID;BETA-CHLOROBUTYRIC ACID;DL-ALPHA-CHLOROBUTYRIC ACID;2-chlorbutyricacid;2-Chlorobutanoic acid
• CAS NO: 4170-24-5
• Molecular Formula: C₄H₇ClO₂
• Molecular Weight: 122.55
• EINECS: 224-029-5
• Product Categories: C1 to C5;Carbonyl Compounds;Carboxylic Acids
• Mol File: 4170-24-5.mol
• Article Data: 22

Chemical Properties

• Melting Point: 76.2-77 °C
• Boiling Point: 90-92 °C12 mm Hg(lit.)
• Flash Point: 112°C
• Appearance: pale yellow liquid
• Density: 1.190 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.116mmHg at 25°C
• Refractive Index: n20/D 1.439
• PKA: 2.86(at RT℃)
• Water Solubility: Soluble in water
• BRN: 1720944
• CAS DataBase Reference: 2-Chlorobutyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chlorobutyric acid(4170-24-5)
• EPA Substance Registry System: 2-Chlorobutyric acid(4170-24-5)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 3
• WGK Germany: 3
• F: 19
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 4170-24-5(Hazardous Substances Data)

Usage

Uses

2-Chlorobutyric acid was used in the synthesis of 2-hydroxy-5-hexenyl 2-chlorobutyrate ester.

Synthesis Reference(s)

The Journal of Organic Chemistry, 40, p. 2960, 1975 DOI: 10.1021/jo00908a025

InChI:InChI=1/C4H7ClO2/c1-2-3(5)4(6)7/h3H,2H2,1H3,(H,6,7)

Upstream product

• 26106-95-6 2-chloro-1-butanol 
• 54235-90-4 ethyl-chloro-malonic acid 
• 141-75-3 butyryl chloride 
• 2835-81-6 2-aminobutanoic acid 
• 107-92-6 butyric acid 
• 74-96-4 ethyl bromide 
• 1492-24-6 L-2-aminobutyric acid 
• 6111-61-1 ethyl(trichloromethyl)carbinol 
• 10026-13-8 phosphorus pentachloride 
• 7553-56-2 iodine 
• 7782-50-5 chlorine 
• 56-23-5 tetrachloromethane 
• 7791-25-5 sulfuryl dichloride 
• 94-36-0 dibenzoyl peroxide 

Downstream Products

• 600-15-7 2-Hydroxybutanoic acid 
• 67648-60-6 2-(4-methoxy-phenoxy)-butyric acid 
• 59011-95-9 2-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-butyric acid 
• 23703-74-4 C₁₂H₁₄Cl₂N₂O₄ 
• 91721-28-7 2-(2-chloro-benzylamino)-5-ethyl-thiazol-4-one 
• 91721-29-8 2-(4-chloro-benzylamino)-5-ethyl-thiazol-4-one 
• 93431-35-7 5-ethyl-2-(3-methyl-benzylamino)-thiazol-4-one 
• 92107-96-5 5-ethyl-2-(4-methyl-benzylamino)-thiazol-4-one 
• 91720-87-5 2-(4-bromo-benzylamino)-5-ethyl-thiazol-4-one 
• 92292-52-9 2-(2,5-dimethyl-benzylamino)-5-ethyl-thiazol-4-one 
• 92292-53-0 2-(3,4-dimethyl-benzylamino)-5-ethyl-thiazol-4-one 
• 92292-51-8 2-(2,4-dimethyl-benzylamino)-5-ethyl-thiazol-4-one 
• 600-12-4 (S)-2-chlorobutyric acid 
• 91566-49-3 2-benzylamino-5-ethyl-thiazol-4-one 

Relevant articles and documents

Preparation method for 2-chloro-butyric acid

The invention discloses a preparation method for 2-chloro-butyric acid. The preparation method comprises the following steps: taking butyric acid as raw material, chlorine as chlorinating agent, acylating chlorination reagent as catalyst and quinone compound as radical scavenger, and then reacting, thereby acquiring a target product 2-chloro-butyric acid. The preparation method has the advantagesof simple process, high selectivity, high production safety and low cost.

A Straightforward Homologation of Carbon Dioxide with Magnesium Carbenoids en Route to α-Halocarboxylic Acids

The homologation of carbon dioxide with stable, (enantiopure) magnesium carbenoids constitutes a valuable method for preparing α-halo acid derivatives. The tactic features a high level of chemocontrol, thus enabling the synthesis of variously functionalized analogues. The flexibility to generate magnesium carbenoids through sulfoxide-, halogen- or proton- Mg exchange accounts for the wide scope of the reaction. (Figure presented.).

Reactions of α-carbanions of lithium acylates with N,N-diethyl-N-chloro- and N,N-diethyl-N-bromoamines

The interaction of α-carbanions of lithium acylates (prepared via metalation of acetic, butyric, or isobutyric acid with lithium diisopropylamide in tetrahydrofuran under argon atmosphere) with N,N-diethyl-N-chloro- or N,N-diethyl-N-bromoamine has resulte