41720-60-9

Basic information

• Product Name: trans-2-(5-methyl-5-vinyltetrahydrofuran-2-yl propan-2-ol)
• CAS NO: 41720-60-9
• Molecular Weight: 170.252
• Mol File: 41720-60-9.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: trans-2-(5-methyl-5-vinyltetrahydrofuran-2-yl propan-2-ol)(CAS DataBase Reference)
• NIST Chemistry Reference: trans-2-(5-methyl-5-vinyltetrahydrofuran-2-yl propan-2-ol)(41720-60-9)
• EPA Substance Registry System: trans-2-(5-methyl-5-vinyltetrahydrofuran-2-yl propan-2-ol)(41720-60-9)

Safety Data

• Hazardous Substances Data: 41720-60-9(Hazardous Substances Data)

Upstream product

• 78-70-6 3,7-dimethylocta-1,6-dien-3-ol 
• 126-90-9 (S)-(+)-linalool 
• 19493-09-5 Methylenetriphenylphosphorane 
• 364045-87-4 (2S,5S)-2-hydrocarbonyl-5-(1-hydroxyl-1-methylethyl)-2-methyltetrahydrofuran 
• 123-35-3 7-methyl-3-methene-1,6-octadiene 
• 917-64-6 methyl magnesium iodide 
• 40036-54-2 (E)-5-(3,3-dimethyloxiran-2-yl)-3-methylpent-2-en-1-ol 
• 106-24-1 Geraniol 
• 85217-73-8 (Z)-3,7-dimethylocta-2,6-dien-1-yl methyl carbonate 
• 106-25-2 Nerol 
• 188579-26-2 Carbonic acid (E)-6,7-dihydroxy-3,7-dimethyl-oct-2-enyl ester ethyl ester 
• 128344-89-8 syn-N-<1-(5-ethenyltetrahydro-5-methylfuran-2-yl)-1-methylethoxy>-2,2,6,6-tetramethylpiperidine 
• 128344-89-8 anti-N-<1-(5-ethenyltetrahydro-5-methylfuran-2-yl)-1-methylethoxy>-2,2,6,6-tetramethylpiperidine 
• 27200-84-6 methyl triphenylphosphonium bromide 

Relevant articles and documents

One-pot synthesis at room temperature of epoxides and linalool derivative pyrans in monolacunary Na7PW11O39-catalyzed oxidation reactions by hydrogen peroxide

In this work, we describe a new one-pot synthesis route of valuable linalool oxidation derivatives (i.e., 2-(5-methyl-5-vinyltetrahydrofuran-2-yl propan-2-ol) (1a)), 2,2,6-trimethyl-6-vinyltetrahydro-2H-pyran-3-ol (1b) and diepoxide (1c), using a green oxidant (i.e., hydrogen peroxide) under mild conditions (i.e., room temperature). Lacunar Keggin heteropolyacid salts were the catalysts investigated in this reaction. Among them, Na7PW11O39 was the most active and selective toward oxidation products. All the catalysts were characterized by FT-IR, TG/DSC, BET, XRD analyses and potentiometric titration. The main reaction parameters were assessed. Special attention was dedicated to correlating the composition and properties of the catalysts and their activity.

Antimalarial Properties of Simplified Kalihinol Analogues

Several kalihinol natural products, members of the broader isocyanoterpene family of antimalarial agents, are potent inhibitors of Plasmodium falciparum, the agent of the most severe form of human malaria. Our previous total synthesis of kalihinol B provided a blueprint to generate many analogues within this family, some as complex as the natural product and some much simplified and easier to access. Each analogue was tested for blood-stage antimalarial activity using both drug-sensitive and -resistant P. falciparum strains. Many considerably simpler analogues of the kalihinols retained potent activity, as did a compound with a different decalin scaffold made in only three steps from sclareolide. Finally, one representative compound showed reasonable stability toward microsomal metabolism, suggesting that the isonitrile functional group that is critical for activity is not an inherent liability in these compounds.

Biotransformations of terpenes by fungi from amazonian Citrus plants

The biotransformations of (RS)-linalool (1), (S)-citronellal (2), and sabinene (3) with fungi isolated from the epicarp of fruits of Citrus genus of the Amazonian forest (i.e., C. limon, C. aurantifolia, C. aurantium, and C. paradisiaca) are reported. The