41721-01-1

Basic information

• Product Name: 2-Pyrrolidinecarboxamide,N,N-diethyl-,(2S)-(9CI)
• Synonyms: 2-Pyrrolidinecarboxamide,N,N-diethyl-,(2S)-(9CI)
• CAS NO: 41721-01-1
• Molecular Formula: C₉H₁₈N₂O
• Molecular Weight: 0
• Product Categories: PYRROLE
• Mol File: 41721-01-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Pyrrolidinecarboxamide,N,N-diethyl-,(2S)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinecarboxamide,N,N-diethyl-,(2S)-(9CI)(41721-01-1)
• EPA Substance Registry System: 2-Pyrrolidinecarboxamide,N,N-diethyl-,(2S)-(9CI)(41721-01-1)

Safety Data

• Hazardous Substances Data: 41721-01-1(Hazardous Substances Data)

Upstream product

• 50888-83-0 (S)-N,N-diethyl-N^α-(benzyloxycarbonyl)prolinamide 
• 934548-19-3 1-(tert-butoxycarbonyl)-2-(S)-(N,N-diethylaminocarbonyl)pyrrolidine 
• 934548-20-6 N-(chloromethyloxycarbonyl)-L-proline diethylamide 
• 3392-10-7 tert-butoxycarbonyl-L-proline N-hydroxysuccinimide ester 
• 105414-01-5 Cbz-L-Pro-OCO₂-i-Bu 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 

Downstream Products

• 104388-31-0 (S)-1-Cyclohex-1-enyl-pyrrolidine-2-carboxylic acid diethylamide 
• 1092844-41-1 1-(2-methyl-4-(2,3,4,5-tetrahydro-1-benzazepin-1-ylcarbonyl)benzylcarbamoyl)-L-proline-N,N-diethylamide 

Relevant articles and documents

Orthogonal Catalysis for an Enantioselective Domino Inverse-Electron Demand Diels?Alder/Substitution Reaction

An enantioselective domino process for the synthesis of substituted 1,2-dihydronaphthalenes has been developed by the combination of chiral amines and a bidentate Lewis acid in an orthogonal catalysis. This new method is based on an inverse electron-demand Diels?Alder and a subsequent group exchange reaction. An enamine is generated in situ from an aldehyde and a chiral secondary amine catalyst that reacts with phthalazine, activated by the coordination to a bidentate Lewis acid catalyst. The absolute configuration of the product is controlled by chiral information provided by the amine. The formed ortho-quinodimethane intermediate is then transformed via a group exchange reaction with thiols. The new method shows a broad scope and tolerates a wide range of functional groups with enantiomeric ratios up to 91 : 9. All-in-all, this enantioselective synthesis tool provides an easy access to complex 1,2-dihydronaphthalenes starting from readily available phthalazine, aldehydes and thiols in a combinatorial way.

New benzylureas as a novel series of potent, nonpeptidic vasopressin V2 receptor agonists

Vasopressin (AVP) is a hormone that stimulates an increase in water permeability through activation of V2 receptors in the kidney. The analogue of AVP, desmopressin, has proven an effective drug for diseases where a reduction of urine output is desired. However, its peptidic nature limits its bioavailability. We report herein the discovery of potent, nonpeptidic, benzylurea derived agonists of the vasopressin V2 receptor. We describe substitutions on the benzyl group to give improvements in potency and subsequent modifications to the urea end group to provide improvements in solubility and increased oral efficacy in a rat model of diuresis. The lead compound 20e (VA106483) is reported for the first time and has been selected for clinical development.

Amino acids and peptides. XVI. Synthesis of N-terminal tetrapeptide analogs of fibrin α-chain and their inhibitory effects on fibrinogen/thrombin clotting

N-Terminal tetrapeptide analogs of fibrin α-chain were synthesized by the solution method using a new active ester, the ester of the oxime of p-nitroacetophenone, and by the solid-phase method. Their inhibitory effects on fibrinogen/thrombin clotting were examined. Of the synthetic peptides, amide analogs of Gly-Pro-Arg-Pro exhibited a more potent inhibitory effect.