41727-58-6

Basic information

• Product Name: 3,5-DICHLORO-4-METHOXYBENZOIC ACID
• Synonyms: 4-Carboxy-2,6-dichloroanisole;BUTTPARK 120\07-66;CHEMBRDG-BB 6628384;3,5-DICHLORO-4-METHOXYBENZOIC ACID;3,5-DICHLORO-4-METHOXYBENZENECARBOXYLIC ACID;AKOS BBS-00006814
• CAS NO: 41727-58-6
• Molecular Formula: C₈H₆Cl₂O₂
• Molecular Weight: 221.04
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 41727-58-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 199-200°C
• Boiling Point: 296℃
• Flash Point: 131℃
• Appearance: /
• Density: 1.376
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3,5-DICHLORO-4-METHOXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DICHLORO-4-METHOXYBENZOIC ACID(41727-58-6)
• EPA Substance Registry System: 3,5-DICHLORO-4-METHOXYBENZOIC ACID(41727-58-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 41727-58-6(Hazardous Substances Data)

Usage

General Description

3,5-Dichloro-4-methoxybenzoic acid is a chemical compound with the molecular formula C8H6Cl2O3. It is an aromatic carboxylic acid with two chlorine atoms and one methoxy group attached to a benzene ring. 3,5-Dichloro-4-methoxybenzoic acid is often used as a herbicide due to its ability to inhibit the enzyme protoporphyrinogen oxidase, which is essential for plant growth. In addition to its herbicidal properties, 3,5-Dichloro-4-methoxybenzoic acid is also used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is important to handle this chemical with care as it may cause irritation to the skin, eyes, and respiratory system if not properly handled.

InChI:InChI=1S/C8H6Cl2O2/c1-12-8-6(9)2-5(4-11)3-7(8)10/h2-4H,1H3

Upstream product

• 4892-23-3 3,5-dichloro-4-methoxybenzyl alcohol 
• 24295-27-0 methyl 3,5-dichloro-4-methoxybenzoate 
• 2314-36-5 3,5-dichloro-4-hydroxybenzaldehyde 
• 74-88-4 methyl iodide 

Downstream Products

• 27164-12-1 C₁₀H₉Cl₂NO₃ 
• 3336-38-7 3,5-dichloro-4-methyloxybenzonitrile 
• 213470-64-5 (+/-)-1-(3',5'-dichloro-4'-methoxyphenyl)-1-propanol 
• 37908-97-7 3,5-dichloro-4-methoxybenzoic acid 
• 249757-10-6 [(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetonitrile 
• 441284-62-4 (Z)-2,6-dichloro-4-(1'-propenyl)anisole 
• 193073-55-1 [(S)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetic acid methyl ester 
• 213470-65-6 1-(3',5'-dichloro-4'-methoxyphenyl)-1-propanone 
• 213470-68-9 1-(3,5-Dichloro-4-methoxy-phenyl)-2-hydroxy-propan-1-one 
• 1027152-07-3 1-[4-(methylsulfonyl)phenyl]-2-(4-methoxy-3,5-dichlorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole 

Relevant articles and documents

SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS

The present invention relates generally to substituted isoquinolines and their use as tubulin polymerization inhibitors. In particular, the invention relates to substituted isoquinolines which possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds

Induction of apoptosis in cancer cells

The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of cancer or for treating disease conditions caused by apoptosis of cells.

Synthesis of (1R,2S)-1-(3′-chloro-4′-methoxyphenyl)-1,2- propanediol (trametol) and (1R,2S)-1-(3′,5′-dichloro-4′- methoxyphenyl)-1,2-propanediol, chlorinated fungal metabolites in the natural environment

(1R,2S)-1-(3′-Chloro-4′-methoxyphenyl)-1,2-propanediol (Trametol, 3), a metabolite of the fungus Trametes sp. IVP-F640 and Bjerkandera sp. BOS55, was synthesized by employing Sharpless asymmetric dihydroxylation as the key step. Similarly, the (1R,2S)-isomer of 1-(3′,5′-dichloro- 4′-methoxyphenyl)-1,2-propanediol (4), another metabolite of Bjerkandera sp. BOS55, was synthesized by asymmetric dihydroxylation.