417726-36-4

Basic information

• Product Name: (S)-N-Boc-1,2,3,6-Tetrahydro-2-picolinic acid
• Synonyms: (S)-N-Boc-1,2,3,6-Tetrahydro-2-picolinic acid;(S)-N-Boc-1,2,3,6-tetrahydro-2-pyridinecarboxylic acid;(S)-1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridine-2-carboxylic acid
• CAS NO: 417726-36-4
• Molecular Formula: C₁₁H₁₇NO₄
• Molecular Weight: 227.26
• Mol File: 417726-36-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 355.2°C at 760 mmHg
• Flash Point: 168.6°C
• Appearance: /
• Density: 1.194g/cm³
• Vapor Pressure: 5.31E-06mmHg at 25°C
• Refractive Index: 1.512
• BRN: 9049382
• CAS DataBase Reference: (S)-N-Boc-1,2,3,6-Tetrahydro-2-picolinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-Boc-1,2,3,6-Tetrahydro-2-picolinic acid(417726-36-4)
• EPA Substance Registry System: (S)-N-Boc-1,2,3,6-Tetrahydro-2-picolinic acid(417726-36-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 417726-36-4(Hazardous Substances Data)

Usage

Description

(S)-N-Boc-1,2,3,6-Tetrahydro-2-picolinic acid is a chemical compound with the molecular formula C14H21NO4. It is a derivative of 2-picolinic acid and is often used as a chiral auxiliary in organic synthesis. (S)-N-Boc-1,2,3,6-Tetrahydro-2-picolinic acid has a Boc (tert-butoxycarbonyl) protecting group attached to the nitrogen atom, which helps to control the stereochemistry of reactions. (S)-N-Boc-1,2,3,6-Tetrahydro-2-picolinic acid is a versatile building block in organic chemistry and is widely used in the synthesis of various pharmaceuticals and biologically active compounds.

Uses

Used in Pharmaceutical Synthesis:
(S)-N-Boc-1,2,3,6-Tetrahydro-2-picolinic acid is used as a chiral auxiliary for controlling the stereochemistry of reactions in the synthesis of pharmaceuticals. Its Boc protecting group ensures precise control over the stereochemical outcome, which is crucial for the development of effective and selective drugs.
Used in Biologically Active Compounds Synthesis:
(S)-N-Boc-1,2,3,6-Tetrahydro-2-picolinic acid is used as a key building block in the synthesis of biologically active compounds. Its unique structure and the presence of the Boc protecting group make it a valuable tool for creating molecules with specific biological activities.
Used in Agrochemical Development:
(S)-N-Boc-1,2,3,6-Tetrahydro-2-picolinic acid is used as a chiral auxiliary in the development of new agrochemicals. Its ability to control stereochemistry is essential for creating effective and selective pesticides, herbicides, and other agricultural products.
Used in Materials Science:
(S)-N-Boc-1,2,3,6-Tetrahydro-2-picolinic acid is used as a building block in the development of new materials with specific properties. Its unique structure and the Boc protecting group allow for the creation of materials with tailored characteristics for various applications in materials science.

InChI:InChI=1/C11H17NO4/c1-11(2,3)16-10(15)12-7-5-4-6-8(12)9(13)14/h4-5,8H,6-7H2,1-3H3,(H,13,14)/t8-/m0/s1

Upstream product

• 417726-35-3 2-formyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 417726-33-1 (S)-N-tert-butoxycarbonyl-1-[(S)-1',2',3',6'-tetrahydropyridin-2-yl]-ethan-1,2-diol 
• 417726-32-0 (2S,3S)-N-allyl-N-tert-butoxycarbonyl-3-amino-5-hexen-1,2-diol 
• 31456-71-0 (2S)-1,2,3,6-tetrahydropyridine-2-carboxylic acid 
• 198646-60-5 (S)-1-(tertbutyloxycarbonyl)-4-oxo-piperidine-2-carboxylic acid 
• 1799811-83-8 1-(tert-butyl)-2-methyl-(S)-4-oxopiperidine-1,2-dicarboxylate 
• 1448668-01-6 1-tert-butyl 2-methyl (2S)-4-hydroxypiperidine-1,2-dicarboxylate 
• 1228430-37-2 (S)-1-tert-butyl 2-methyl 2,3-dihydropyridine-1,2(6H)-dicarboxylate 

Downstream Products

• 26250-84-0 (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid 
• 1228430-37-2 (S)-1-tert-butyl 2-methyl 2,3-dihydropyridine-1,2(6H)-dicarboxylate 
• 1228430-38-3 1-(1,1-dimethylethyl) (2S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 1228430-39-4 (2S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-1,2,3,6-tetrahydropyridine 
• 1228430-40-7 (2S)-2-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-1-[(4-methylphenyl)sulfonyl]-1,2,3,6-tetrahydropyridine 
• 1228430-41-8 (1R,4S,6R)-4-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-3-[(4-methylphenyl)sulfonyl]-3-azabicyclo[4.1.0]heptane 
• 1228430-55-4 (1R,4S,6R)-4-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-3-azabicyclo[4.1.0]heptane 
• 1252905-76-2 (1R,4S,6R)-4-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-3-{[6-methyl-3-(2-pyrimidinyl)-2-pyridinyl]carbonyl}-3-azabicyclo[4.1.0]heptane 
• 1394170-11-6 C₁₆H₁₉N₃O₃ 
• 1394169-88-0 (S)-1-(2-(4-chlorophenyl)acetyl)-N-(4-(3-oxomorpholino)phenyl)-1,2,3,6-tetrahydropyridine-2-carboxamide 
• 1394169-87-9 (S)-tert-butyl 6-(4-(3-oxomorpholino)phenylcarbamoyl)-5,6-dihydropyridine-1(2H)-carboxylate 

Relevant articles and documents

Substituted piperidine amide derivative, preparation method thereof, and application of derivative to pharmacy

The invention relates to a substituted piperidine amide derivative as shown in a general formula (I) or a stereisomer and pharmaceutically acceptable salt thereof, a preparation method of the derivative, medicinal combination as well as application of the derivative to the aspects of local anaesthesia or analgesia. The definition of each group of the general formula (I) is consistent with that of the description. (The general formula (I) is as shown in the description).

Asymmetric synthesis of cis-4- and trans-3-hydroxypipecolic acids

Enantioselective syntheses of cis-4- and trans-3-hydroxypipecolic acids from 2,3-epoxy-5-hexen-1-ol (7) are described. Regioselective C-3 or C-2 ring opening of the epoxide by the appropriate nitrogen nucleophile is the key step in each route. As enantiom