41803-68-3

Basic information

• Product Name: Pyrido[2,3-d]pyrimidin-4-amine, 2-phenyl-
• CAS NO: 41803-68-3
• Molecular Formula: C13H10N4
• Molecular Weight: 222.249
• Mol File: 41803-68-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Pyrido[2,3-d]pyrimidin-4-amine, 2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[2,3-d]pyrimidin-4-amine, 2-phenyl-(41803-68-3)
• EPA Substance Registry System: Pyrido[2,3-d]pyrimidin-4-amine, 2-phenyl-(41803-68-3)

Safety Data

• Hazardous Substances Data: 41803-68-3(Hazardous Substances Data)

Upstream product

• 112084-93-2 2-(benzoylamino)-3-cyanopyridine 
• 41803-67-2 4-chloro-2-phenylpyrido[2,3-d]pyrimidine 
• 98-88-4 benzoyl chloride 
• 24517-64-4 2-amino-3-pyridinecarbonitrile 
• 82216-41-9 2-amino-3-(5'-phenyl-1',2',4'-oxadiazolyl-3')pyridine 

Relevant articles and documents

Convenient and practical one-pot synthesis of 4-chloropyrimidines via a novel chloroimidate annulation

Reaction of aromatic or heteroaromatic 2-acyl(amino)nitriles with phosphorus pentachloride triggers a novel chloroimidate cyclization, leading directly to the corresponding annullated 4-chloropyrimidines in good to excellent yields. The reaction lends itself to the telescoped one-pot construction of 4-functionalized pyrimidines from the corresponding (hetero)aromatic 2-aminonitriles. For a pyrazolopyrimidine development intermediate, this reaction was scaled up to multikilogram scale with excellent results. A total of 10 examples with different substrates are provided. This one-pot reaction provides an attractive and sustainable alternative to the commonly used multistep methodology for this transformation.