41841-19-4

Basic information

• Product Name: Benzeneacetic acid, 2,4,6-triMethyl-, Methyl ester
• Synonyms: Benzeneacetic acid, 2,4,6-triMethyl-, Methyl ester;Methyl 2-Mesitylacetate
• CAS NO: 41841-19-4
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.25424
• Mol File: 41841-19-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzeneacetic acid, 2,4,6-triMethyl-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 2,4,6-triMethyl-, Methyl ester(41841-19-4)
• EPA Substance Registry System: Benzeneacetic acid, 2,4,6-triMethyl-, Methyl ester(41841-19-4)

Safety Data

• Hazardous Substances Data: 41841-19-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 4408-60-0 2-mesitylacetic acid 
• 50690-12-5 2-chloro-1-(2,4,6-trimethyl-phenyl)-ethanone 
• 108-67-8 1,3,5-trimethyl-benzene 
• 487-68-3 mesytaldehyde 
• 77295-61-5 1,1-Dibrom-2-(2,4,6-trimethylphenyl)ethylen 

Downstream Products

• 125640-54-2 Methyl 2-Mesityl-3-methylbutanoate 
• 4408-60-0 2-mesitylacetic acid 
• 20732-28-9 2-Mesityl-3-methylbutanoic Acid 
• 125640-55-3 2-Mesityl 3-methylbutanoyl chloride 
• 125640-47-3 1,2-Dimesityl-3-methylbutan-1-one 
• 87077-43-8 2-methyl-1-(2,4,6-trimethyl-phenyl)-propan-2-ol 
• 1255943-90-8 4-hydroxy-8-methoxy-3-(2,4,6-trimethyl-phenyl)-1-oxa-8-aza-spiro[4.5]dec-3-en-2-one 
• 1256917-24-4 3-[1-methoxy-4-(4-methoxy-benzylsulfanyl)-piperidin-4-yl]-3-oxo-2-(2,4,6-trimethyl-phenyl)-propionic acid methyl ester 
• 1309925-32-3 8-dimethylamino-3-(2,4,6-trimethyl-phenyl)-1-oxa-8-aza-spiro[4.5]decane-2,4-dione 
• 1612831-38-5 C₃₀H₄₁F₃O₄SSi 
• 1612831-31-8 C₂₃H₂₆O₃S 
• 1612831-47-6 methyl 7-(benzyloxy)-5-hydroxy-2-mesityl-6-methyl-3-oxoheptanoate 
• 1612831-48-7 6-(1-(benzyloxy)propan-2-yl)-3-mesityldihydro-2H-pyran-2,4-(3H)-dione 
• 1612831-49-8 2-(1-(benzyloxy)propan-2-yl)-5-mesityl-6-oxo-3,6-dihydro-2H-pyran-4-yl pivalate 

Relevant articles and documents

Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-ones as potassium-competitive acid blockers

With the aim to discover a gastric antisecretory agent more potent than the existing proton pump inhibitors, novel 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-one derivatives, which could occupy two important lipophilic pockets (described as LP-1 and LP-2) of H+,K+-ATPase and can strongly bind to the K+-binding site, were designed based on a docking model. Among the compounds synthesized, compound 4d showed a strong H+,K+-ATPase-inhibitory activity and a high stomach concentration in rats, resulting in potent inhibitory action on histamine-stimulated gastric acid secretion in rats. Furthermore, 4d exerted significant inhibitory action on histamine-stimulated gastric-acid secretion in rats with a rapid onset and moderate duration of action after the administration. These findings may lead to a new insight into the drug design of potassium-competitive acid blockers.

NOVEL BETA MIMETICS WITH EXTENDED DURATION OF ACTION, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS

The invention relates to compounds of general formula (I), where the groups R1, R2 and R3 can have the meanings given in the claims and the description, method for production and use thereof as medicaments, in particular for the treatment of inflammatory and obstructive bronchial diseases.

Unusual Kinetic Stability of Enols to Ketonization: 1,2-Dimesityl-3-methylbut-1-en-1-ol and Related β-Alkyl-α,β-dimesitylethenols

The β-alkyl-α,β-dimesitylethenols 3 and the isomeric β-alkyl-α,β-dimesitylethanones 4 (β-alkyl = Me, Et, i-Pr) were prepared and their spectral properties are reported.X-ray diffraction of the β-isopropyl enol 3d showed that the two mesityl rings are near