41873-65-8

Basic information

• Product Name: ethyl (2-hydroxyphenyl)acetate
• Synonyms: (2-Hydroxyphenyl)acetic acid ethyl ester;2-Hydroxybenzeneacetic acid ethyl ester;Ethyl 2-(2-hydroxyphenyl)acetate;2-(2-Hydroxyphenyl)acetic Acid Ethyl Ester
• CAS NO: 41873-65-8
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2005
• EINECS: 255-572-6
• Product Categories: Aromatics;Intermediates
• Mol File: 41873-65-8.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 105°C@0.35-0.45mmHg.
• Flash Point: 115.3°C
• Appearance: /
• Density: 1.146g/cm³
• Vapor Pressure: 0.0026mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: -20?C Freezer
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• Stability: Store in Freezer
• CAS DataBase Reference: ethyl (2-hydroxyphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (2-hydroxyphenyl)acetate(41873-65-8)
• EPA Substance Registry System: ethyl (2-hydroxyphenyl)acetate(41873-65-8)

Safety Data

• Hazardous Substances Data: 41873-65-8(Hazardous Substances Data)

Usage

Description

Ethyl (2-hydroxyphenyl)acetate, also known as Ethyl 2-Hydroxyphenylacetate, is a light yellow liquid with unique chemical properties. It is a synthetic intermediate that plays a significant role in the development of pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
Ethyl (2-hydroxyphenyl)acetate is used as a synthetic intermediate for the preparation of novel anti-inflammatory agents. Its chemical structure allows for the creation of new compounds that can potentially offer relief from inflammation and related conditions.
As a synthetic intermediate, ethyl (2-hydroxyphenyl)acetate is crucial in the development of new medications, particularly those aimed at treating inflammation. Its light yellow liquid form and unique chemical properties make it a valuable component in the pharmaceutical industry's ongoing efforts to create effective and innovative treatments for various health issues.

InChI:InChI=1/C10H12O3/c1-2-13-10(12)7-8-5-3-4-6-9(8)11/h3-6,11H,2,7H2,1H3

Upstream product

• 64-17-5 ethanol 
• 614-75-5 2-Hydroxyphenylacetic acid 
• 141-78-6 ethyl acetate 
• 90-02-8 salicylaldehyde 
• 101-97-3 Ethyl 2-phenylethanoate 

Downstream Products

• 101790-50-5 2,4-bis-(2-hydroxy-phenyl)-acetoacetic acid ethyl ester 
• 156005-36-6 [2-(3-Bromo-propoxy)-phenyl]-acetic acid ethyl ester 
• 186135-55-7 4-Ethoxy-2H,5H-1-benzoxepin-2-one 
• 875629-44-0 [2-(4-bromo-2-fluoro-benzyloxy)-phenyl]-acetic acid ethyl ester 
• 916908-22-0 [2-(4-fluoro-benzyloxy)-phenyl]-acetic acid ethyl ester 

Relevant articles and documents

Insights into Ruthenium(II/IV)-Catalyzed Distal C?H Oxygenation by Weak Coordination

C?H hydroxylation of aryl acetamides and alkyl phenylacetyl esters was accomplished via challenging distal weak O-coordination by versatile ruthenium(II/IV) catalysis. The ruthenium(II)-catalyzed C?H oxygenation of aryl acetamides proceeded through C?H ac

Transition-Metal-Free Synthesis of 2-Substituted Methyl Benzo[b]furan-3-carboxylates

A concise and highly efficient synthetic pathway was developed for 2-substituted methyl benzo[b]furan-3-carboxylates. This method provides convenient and cost-effective access for 2-substituted methyl benzo[b]furan-3-carboxylates without the use of a transition metal catalyst for synthesis. Furthermore, in most cases, this method gives excellent yields and conventional flash column chromatography is not needed for purification.

Synthesis of 3-hydroxyindanones via potassium salt of amino acid catalyzed regioselective intramolecular aldolization of ortho-diacylbenzenes

First organocatalytic intramolecular aldolization of ortho-diacylbenzenes to construct highly functionalized 3-hydroxyindanones is described. In this transformation a high trans-selectivity is achieved by the use of metal salt of amino acid. This method allows an easy access to the strained spirocyclic 3-hydroxyindanones related to a number of natural product frameworks. Synthesis of a new class of indole skeleton substituted by 3-hydroxyindanones added an extra essence to this new protocol.