41888-62-4

Basic information

• Product Name: 2-Methyl-4-(1,3-benzodioxole-5-ylmethylene)-2-oxazoline-5-one
• Synonyms: 2-Methyl-4-(1,3-benzodioxol-5-ylmethylene)oxazol-5(4H)-one;2-Methyl-4-(1,3-benzodioxole-5-ylmethylene)-2-oxazoline-5-one;2-Methyl-4-(3,4-methylenebisoxybenzylidene)oxazol-5(4H)-one;2-Methyl-4-[(1,3-benzodioxol-5-yl)methylene]oxazol-5(4H)-one;4,5-Dihydro-2-methyl-4-(3,4-methylenebisoxybenzylidene)-5-oxooxazole;(4Z)-4-(1,3-benzodioxol-5-ylmethylidene)-2-methyl-1,3-oxazol-5-one;4-(1,3-benzodioxol-5-ylmethylene)-2-methyl-1,3-oxazol-5(4H)-one
• CAS NO: 41888-62-4
• Molecular Formula: C₁₂H₉NO₄
• Molecular Weight: 231.2
• Mol File: 41888-62-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Methyl-4-(1,3-benzodioxole-5-ylmethylene)-2-oxazoline-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-4-(1,3-benzodioxole-5-ylmethylene)-2-oxazoline-5-one(41888-62-4)
• EPA Substance Registry System: 2-Methyl-4-(1,3-benzodioxole-5-ylmethylene)-2-oxazoline-5-one(41888-62-4)

Safety Data

• Hazardous Substances Data: 41888-62-4(Hazardous Substances Data)

Upstream product

• 120-57-0 piperonal 
• 543-24-8 N-acetylglycine 

Downstream Products

• 884-18-4 β-(benzo[1,3]dioxol-5-yl)pyruvic acid 
• 30657-34-2 N-Acetyl-3-<3,4-methylendioxy-phenyl>-DL-alanin 
• 110841-90-2 N-benzyl-3,4-methylenedioxybenzyl-2(1H)-quinoxalinone 
• 5805-83-4 1-benzyl-2-methylbenzimidazole 
• 615-15-6 2-Methyl-1H-benzimidazole 
• 101291-34-3 3,4-methylenedioxybenzyl-2(1H)-quinoxalinone 
• 110841-95-7 N-phenyl-3,4-methylenedioxybenzyl-2(1H)-quinoxalinone 
• 1484-39-5 2-methyl-1-phenyl-1H-benzimidazole 
• 202651-05-6 6-Benzo[1,3]dioxol-5-ylmethyl-3-mercapto-4-{[1-p-tolyl-meth-(E)-ylidene]-amino}-4H-[1,2,4]triazin-5-one 

Relevant articles and documents

Single-Biocatalyst Synthesis of Enantiopure d-Arylalanines Exploiting an Engineered d-Amino Acid Dehydrogenase

A practical and efficient biocatalytic synthesis of aromatic d-amino acids has been developed, based on the reductive amination of the corresponding α-keto acids via a recombinant whole cell system composed of an engineered dehydrogenase and cofactor recycling apparatus. The reaction was shown to give excellent enantioselectivity (≥98%) and good yields at the preparative scale across a broad range of substrates. Additionally, the structure of the variant enzyme was solved to allow rationalisation of the observed reaction rates. The engineered whole cell catalyst was also used to mediate the production of d-phenylalanine derivatives from racemic mixtures and cheaper l-amino acids by combining it with an enantiocomplementary deaminase. (Figure presented.).

M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: Serominic compounds

Chronic low-dose treatment of rats with the psychomimetic drug, phencyclidine, induces regionally specific metabolic and neurochemical changes in the CNS that mirror those observed in the brains of schizophrenic patients. Recent evidence suggests that drugs targeting serotoninergic and muscarinic receptors, and in particular 5-HT7 antagonists and M4 agonists, exert beneficial effects in this model of schizophrenia. Compounds that display this combined pattern of activity we refer to as serominic compounds. Based upon leads from natural product screening, we have designed and synthesised such serominic compounds, which are principally arylamidine derivatives of tetrahydroisoquinolines, and shown that they have the required serominic profile in ligand binding assays and show potential antipsychotic activity in functional assays.

Solid support Erlenmeyer synthesis of azlactones using microwaves

A rapid and efficient protocol for the synthesis of azlactones is reported starting from acetyl/benzoylglycine and various aromatic aldehydes in the presence of acetic anhydride and sodium acetate in dry media using silica gel as solid support under microwave irradiation. The mild conditions, excellent yields, high purity. short reaction time and easy work-up are some of the major advantages of this method.